Main Title |
Effect of Sulfolane on Behavioral and Autonomic Thermoregulation in the Rat. |
Author |
Gordon, C. J. ;
Dyer, R. S. ;
Long, M. D. ;
Fehlner, K. S. ;
|
CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. |
Year Published |
1985 |
Report Number |
EPA/600/J-85/521; |
Stock Number |
PB88-170915 |
Additional Subjects |
Toxicology ;
Thermoregulation ;
Rats ;
Laboratory animals ;
Behavior ;
Reprints ;
Sulfolane
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB88-170915 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
10p |
Abstract |
In one study, colonic temperature, skin temperature and metabolic rate and, in another study, preferred ambient temperature (Ta) were measured over an 8 hr period in the Sprague-Dawley rat following an intraperitoneal injection of 800 mg/kg sulfolane or physiological saline. At Ta's of 15 and 25 C sulfolane caused a significant inhibition in metabolic rate and reduction in colonic temperature which lasted over the 8 hr measuring period. At both Ta's, metabolic rate tended to recover approximately 4 hr after sulfolane injection. Colonic temperature tended to recover with time but was still significantly reduced at 8 hr post-injection. Tail skin temperature was unaffected by sulfolane. Preferred Ta in the sulfolane-treated rat was not significantly different from the controls. Interestingly, in spite of their hypothermic condition, the sulfolane-treated animals did not select a warm Ta which would have elevated their body temperature to normal. |
Supplementary Notes |
Pub. in Jnl. of Toxicology and Environmental Health, v16 p461-468 1985. |
NTIS Title Notes |
Journal article. |
Title Annotations |
Reprint: Effect of Sulfolane on Behavioral and Autonomic Thermoregulation in the Rat. |
PUB Date Free Form |
1985 |
Category Codes |
57Y; 57O |
NTIS Prices |
PC A02/MF A01 |
Primary Description |
600/11 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
812722648 |
Origin |
NTIS |
Type |
CAT |