Main Title |
Differential Effects of Caffeine, Picrotoxin, and Pentylenetetrazol on Hippocampal Afterdischarge Activity and Wet Dog Shakes (Journal Version). |
Author |
Burdette, L. J. ;
Dyer, R. S. ;
|
CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. |
Publisher |
1987 |
Year Published |
1987 |
Report Number |
EPA/600/J-87/414; |
Stock Number |
PB89-105605 |
Additional Subjects |
Analeptics ;
Caffeine ;
Picrotoxin ;
Pentenetetrazol ;
Hippocampus ;
Neurobiology ;
Electroencephalography ;
Laboratory animals ;
Body temperature ;
Reprints ;
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB89-105605 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
15p |
Abstract |
The present experiment was conducted to identify changes in hippocampal after discharge (AD) parameters following administration of subconvulsant dosages (half of the convulsant dosage) of analeptics with known pharmacological action. Long Evans rats (N=104) with chronic bipolar electrodes implanted in the dorsal hippocampus were injected with saline (0 mg/kg), caffeine (75 mg/kg), picrotoxin (2 mg/kg) or pentylenetetrazol (20 mg/kg) 15 minutes before testing. A differential effect of caffeine administration was observed in the dramatic prolongation of the rebound AD, without an accompanying change noted in the duration of the primary AD. Because caffeine blocks adenosine receptors at physiological concentrations, adenosine action is implicated in the termination of the second, but not the first, spike train. Picrotoxin and pentylenetetrazol had no influence on EEG parameters. A decrease in wet dog shake frequency, was associated with picrotoxin. The results suggest that GABA is involved minimally, if at all, in the hippocampal AD sequence. |
Supplementary Notes |
Pub. in Experimental Neurology, v96 p381-392 1987. |
NTIS Title Notes |
Journal article. |
Title Annotations |
Reprint: Differential Effects of Caffeine, Picrotoxin, and Pentylenetetrazol on Hippocampal Afterdischarge Activity and Wet Dog Shakes (Journal Version). |
Category Codes |
57I; 57Q; 57S |
NTIS Prices |
PC A03/MF A01 |
Primary Description |
600/11 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
834421762 |
Origin |
NTIS |
Type |
CAT |