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OLS Field Name OLS Field Data
Main Title Sister-Chromatid Exchange Induction in Rat Maternal, Embryonic and Extra-Embryonic Cells After in vivo Exposure to 4-Nitroquinoline 1-Oxide.
Author Sharma, R. K. ; Dunn, R. ; Allen, J. W. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. Genetic Toxicology Div. ;National Inst. of Environmental Health Sciences, Research Triangle Park, NC.
Year Published 1984
Report Number EPA/600/J-84/379;
Stock Number PB86-209798
Additional Subjects Toxicology ; In vivo analysis ; Rats ; Reprints ; Sister chromatid exchange ; Genotoxicity ; Nitroquinoline oxide
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NTIS  PB86-209798 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/21/1988
Collation 6p
Abstract Genetic damage is associated with various embryo pathologies; and many teratogens and transplacental carcinogens are known to be genotoxic. The present study was aimed at charaterizing SCE induction levels in rodent maternal, embryonic and extra-embryonic cells after maternal exposure to 4NQO. Tissue-specific assessments were made at various gestational ages, and thus stages of placental development. Embryo liver, and yolk sac - the malfunction of which has been implicated in teratogenic mechanisms were assessed with a particular view to whether they would show relatively low levels of SCE induction and thereby lend support to the concept of a protective placental barrier to 4NQO. A previously established rat system allowing for in vivo SCE induction analyses of maternal marrow and embryo liver or yolk sac was used for these studies.
Supplementary Notes Pub. in Mutation Research 139, n3 p139-142 Mar 84. Prepared in cooperation with National Inst. of Environmental Health Sciences, Research Triangle Park, NC.
NTIS Title Notes Journal article.
Title Annotations Reprint: Sister-Chromatid Exchange Induction in Rat Maternal, Embryonic and Extra-Embryonic Cells After in vivo Exposure to 4-Nitroquinoline 1-Oxide.
PUB Date Free Form c1984
Category Codes 6T; 57Y
NTIS Prices PC A02/MF A01
Primary Description 600/11
Document Type NT
Cataloging Source NTIS/MT
Control Number 624110585
Origin NTIS
Type CAT