||Prenatal Effects of Dieldrin and Photodieldrin in Mice and Rats.
Chernoff, Neil ;
Kavlock, Robert J. ;
Kathrein, John R. ;
Dunn, John M. ;
Haseman., Joseph K. ;
||National Environmental Research Center, Research Triangle Park, N.C. Pesticides and Toxic Substances Effects Lab.
||found in PB-280 889
||PB-280 892, found in PB-280 889
Chlorine organic compounds ;
Body weight ;
Lethal dosage ;
Laboratory animals ;
Toxic substances ;
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
||Doses of 1.5, 3.0, and 6.0 mg/kg/day of dieldrin and 0.15, 0.30, and 0.60 mg/kg/day of photodieldrin were administered to pregnant CD-1 mice and CD rats by gastric intubation on days 7-16 of gestation. The highest dose of dieldrin induced significant increases in liver/body weight ratios and reduced weight gain in mice, and resulted in 41% mortality in rats. The highest dose of photodieldrin also induced significant increases in mouse liver/body weight ratios, and resulted in 15% mortality in rats. Teratogenic effects were not observed. The higher doses of dieldrin induced an increase in supernumerary ribs and a concomitant decrease in ossification centers in fetal mice indicating toxicity at these dose levels. Similar changes were not found in the rat. Photodieldrin induced no apparent fetal toxicity in either species.
||contained in PB-280 889 titled Journal Articles on Toxicology. Group 14.
||Pub. in Toxicology and Applied Pharmacology, v31 n2 p302-308, Feb 75.
||Included in the report, Journal Articles on Toxicology, Group 14, PB-280 889.
||Reprint: Prenatal Effects of Dieldrin and Photodieldrin in Mice and Rats,
|PUB Date Free Form
||1 Aug 74
||6T; 57Y; 68G; 68E
||(Order as PB-280 889, MF A01)