||Effects of Diphenylhydatoin and Chloroquine on Monkey Liver Microsomal Mixed-Function Oxidases.
Davis, J. E. ;
Cramer, M. F. ;
Peoples., A. J. ;
||Health Effects Research Lab., Research Triangle Park, N.C. Population Studies Div. ;National Center for Toxicology Research, Jefferson, Ark. ;Miami Univ., Fla. School of Medicine.
Laboratory animals ;
In vitro analysis ;
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
||Sixteen adult male squirrel monkeys (Saimiri sciureus) were randomly divided into three treatment groups and one control group. Each treatment group received 10 mg/kg oral doses of diphenylhydantoin and/or chloroquine. Following sacrifice, in vitro assays for activity of liver microsomal mixed-function oxidases were run. The assays confirmed diphenylhydantoin as a potent inducer of mixed-function oxidases. Chloroquine administration had little affect on the enzymes assayed and did not inhibit the diphenylhydantoin induction. (Copyright (c) 1977 by Hemisphere Publishing Corporation.)
||Prepared in cooperation with National Center for Toxicology Research, Jefferson, Ark., and Miami Univ., Fla. School of Medicine.
||Pub. in Jnl. of Toxicology and Environmental Health 2, p1193-1199 1977.
|NTIS Title Notes
||Reprint: Effects of Diphenylhydatoin and Chloroquine on Monkey Liver Microsomal Mixed-Function Oxidases.
|PUB Date Free Form
||16 Feb 77
||Not available NTIS