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RECORD NUMBER: 46 OF 194

OLS Field Name OLS Field Data
Main Title Effects of Diphenylhydatoin and Chloroquine on Monkey Liver Microsomal Mixed-Function Oxidases.
Author Davis, J. E. ; Cramer, M. F. ; Peoples., A. J. ;
CORP Author Health Effects Research Lab., Research Triangle Park, N.C. Population Studies Div. ;National Center for Toxicology Research, Jefferson, Ark. ;Miami Univ., Fla. School of Medicine.
Year Published 1977
Report Number EPA/600/J-77/093;
Stock Number PB-278 598
Additional Subjects Drugs ; Oxidoreductases ; Enzymes ; Hydantoins ; Monkeys ; Bioassay ; Laboratory animals ; Ribosomes ; Liver ; In vitro analysis ; Reprints ; Hydantoin/diphenyl ; Chloroquine
Holdings
Library Call Number Additional Info Location Last
Modified
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Status
NTIS  PB-278 598 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 06/23/1988
Collation 8p
Abstract Sixteen adult male squirrel monkeys (Saimiri sciureus) were randomly divided into three treatment groups and one control group. Each treatment group received 10 mg/kg oral doses of diphenylhydantoin and/or chloroquine. Following sacrifice, in vitro assays for activity of liver microsomal mixed-function oxidases were run. The assays confirmed diphenylhydantoin as a potent inducer of mixed-function oxidases. Chloroquine administration had little affect on the enzymes assayed and did not inhibit the diphenylhydantoin induction. (Copyright (c) 1977 by Hemisphere Publishing Corporation.)
Supplementary Notes Prepared in cooperation with National Center for Toxicology Research, Jefferson, Ark., and Miami Univ., Fla. School of Medicine.
Availability Notes Pub. in Jnl. of Toxicology and Environmental Health 2, p1193-1199 1977.
NTIS Title Notes Journal article.
Title Annotations Reprint: Effects of Diphenylhydatoin and Chloroquine on Monkey Liver Microsomal Mixed-Function Oxidases.
PUB Date Free Form 16 Feb 77
Category Codes 6O; 57Q
NTIS Prices Not available NTIS
Primary Description 600/11
Document Type NT
Cataloging Source NTIS/MT
Control Number 323737024
Origin NTIS
Type CAT