Main Title |
Mutational Risks in Females: Genomic Imprinting and Maternal Molecules. |
Author |
Wilson, G. N. ;
|
CORP Author |
Texas Univ. Southwestern Medical Center at Dallas. Dept. of Pediatrics.;Environmental Protection Agency, Washington, DC. Office of Health and Environmental Assessment. |
Publisher |
c1992 |
Year Published |
1992 |
Report Number |
EPA/600/J-93/181 ; OHEA-R-484 |
Stock Number |
PB93-194488 |
Additional Subjects |
Mutations ;
Females ;
Mitochondrial DNA ;
Mutagenesis ;
Methylation ;
Hereditary diseases ;
Ribonucleic acids ;
Pedigree ;
Mitochondria ;
Sex chromosomes ;
Reprints ;
Genomic imprinting
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB93-194488 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
11p |
Abstract |
Genetic mechanisms for selective mutagenesis in female mammals might include alterations of genomic imprinting, maternally derived molecules, mitochondrial DNA or sex chromosome loci. None of these mechanisms provides an obvious explanation for the higher mutational rates observed for certain mutagens in mouse female pronuclei, but the association of DNA methylation with maternal genomic imprinting is an enticing avenue for research. Further characterization of the extent and homology of genomic imprinting among mammals is required before its relevance to mutagenesis can be determined. The existence of maternal effect mutations in mammals merits evaluation but is not yet proven. The relevance of mitochondrial DNA to female-specific mutagenesis will be greatest in multi-generational studies. (Copyright (c) 1992 Elsevier Science Publishers B.V.) |
Supplementary Notes |
Pub. in Mutation Research Special Issue, 'Female Germ Cells: Biology and Genetic Risk', v296 n1/2 p157-165 Dec 92. Sponsored by Environmental Protection Agency, Washington, DC. Office of Health and Environmental Assessment. |
NTIS Title Notes |
Journal article. |
Title Annotations |
Reprint: Mutational Risks in Females: Genomic Imprinting and Maternal Molecules. |
Category Codes |
57F |
NTIS Prices |
PC A03/MF A01 |
Primary Description |
600/21 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
318932009 |
Origin |
NTIS |
Type |
CAT |