Main Title |
Concentration of O,P'-DDT in Rat Brain at Various Intervals after Dosing. |
Author |
Dale, W. E. ;
Copeland, M. F. ;
Pearce, G. W. ;
Miles., J. W. ;
|
CORP Author |
Communicable Disease Center, Atlanta, Ga. |
Year Published |
1965 |
Stock Number |
PB-279 749 |
Additional Subjects |
DDT ;
Pesticides ;
Toxicology ;
Concentration(Composition) ;
Rats ;
Brain ;
Laboratory animals ;
Experimental data ;
Dosage ;
Lethal dosage ;
Ingestion(Biology) ;
Bioassay ;
Toxicity ;
Reprints ;
Toxic substances
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB-279 749 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
4p |
Abstract |
At the same oral dosage of 150 mg/kg, p,p'-DDT produces severe illness in all rats and kills about half of them, but o,p'-DDT produced no illness. However, the concentration of o,p'-DDT in the brain at various intervals after dosing was about the same as that reported by Dale et al. for p,p'-DDT given at the same dosage. At a dosage of 3000 mg/kg, o,p'-DDT produces mild to moderate illness and the concentration in the brain was 5 to 9 times the concentration of p,p'-DDT required to produce similar symptoms. The ethylene derivative of o,p'-DDT (o,p'-DDE) was not detected in any of the brains. Thus, p,p'-DDT appears to be inherently more toxic than the o,p'-isomer. |
Supplementary Notes |
Pub. in Arch. int. Pharmacodyn., 162, n1 p40-43 1966. |
Availability Notes |
Included in the report, Journal Articles on Toxicology. Group 8, PB-279 739. |
Title Annotations |
Reprint: Concentration of O,P'-DDT in Rat Brain at Various Intervals after Dosing, |
PUB Date Free Form |
8 Feb 65 |
Category Codes |
6T; 57Y; 68G; 68E |
NTIS Prices |
(Order as PB-279 739, MF A01) |
Primary Description |
500/01 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
323739157 |
Origin |
NTIS |
Type |
CAT |