||Effects of the Benomyl Metabolite, Carbendazim, on the Hypothalamic-Pituitary Reproductive Axis in the Male Rat.
Goldman, J. M. ;
Rehnberg, G. L. ;
Cooper, R. L. ;
Gray, L. E. ;
Hein., J. F. ;
||Health Effects Research Lab., Research Triangle Park, NC. ;NSI Technology Services Corp., Research Triangle Park, NC.
Hypothalamo-hypophyseal system ;
Pituitary hormone releasing hormones ;
Organ weight ;
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
||Carbendazim (MBC), the bioactive metabolite of the fungicide benomyl, has been reported to induce a number of testicular alterations in male rats. In order to broaden an exploration of its effects on the reproductive system, the present study focused on the possible presence of concurrent endocrine changes in the hypothalamic and pituitary components of the brain-pituitary-testicular axis. Subchronic administration of MBC (50, 100, 200 or 400 mg/kg) was found to cause a dose-related elevation in serum follicle-stimulating hormone (FSH) and pituitary luteinizing hormone (LH). Values for prolactin and thyroid-stimulating hormone remained unchanged. The effect on FSH was associated with fertility status and independent of serum testosterone. It may be linked to alterations in Sertoli cell-pituitary signaling. Changes in pituitary LH at 400 mg/kg were unrelated to fertility and suggest an influence of MBC on LH metabolism. (Copyright (c) 1989 Elsevier Scientific Publishers Ireland Ltd.)
||Pub. in Toxicology 57, p173-182 1989. Prepared in cooperation with NSI Technology Services Corp., Research Triangle Park, NC.
|NTIS Title Notes
||Reprint: Effects of the Benomyl Metabolite, Carbendazim, on the Hypothalamic-Pituitary Reproductive Axis in the Male Rat.
||PC A03/MF A01