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OLS Field Name OLS Field Data
Main Title Health assessment document for tetrachloroethylene (perchloroethylene).
Author Benignus, V. ; Chen, C. W. ; Gibb, H. J. ; Greenberg, M. M. ; Hiremath, C. B.
CORP Author Environmental Protection Agency, Washington, DC. Office of Health and Environmental Assessment.
Publisher U.S. Environmental Protection Agency, Office of Research and Development, Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office,
Year Published 1985
Report Number EPA/600/8-82/005F
Stock Number PB85-249704
Subjects Tetrachlorides--Toxicology--United States. ; Air--Pollution--Physiological effect--United States. ; Air--Pollution--United States--Physiological effect
Additional Subjects Tetrachloroethylene ; Toxicology ; Exposure ; Laboratory animals ; Assessments ; Malignant neoplasms ; Liver ; Bacteria ; Toxic substances ; Occupational safety and health ; Pharmacokinetics ; Environmental health
Library Call Number Additional Info Location Last
NTIS  PB85-249704 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 01/01/1988
Collation 268 pages : illustrations ; 28 cm
Abstract Tetrachloroethylene (PCE) is a volatile solvent with important commercial applications. It has been detected in the ambient air of a variety of urban and nonurban areas of the United States. It has less frequently been detected in water but has been monitored generally at levels of 1 ppb or less. The lowest-observed-adverse-effect-level, based on central nervous system dysfunction, is about 100 ppm. Toxicity testing in experimental aminals, coupled with limited human data, suggests that long term exposure of humans to ambient levels of PCE is not likely to represent a health concern. At the current time, the teratogenic potential of PCE for humans is unknown; the mammalian animal tests performed to date do not indicate any significant teratogenic potential. Although PCE epoxide has been found to be positive with respect to mutagenicity in bacterial systems, the data on pure PCE suggest that if it is mutagenic, it is a weak mutagen. PCE has been demonstrated to induce malignant tumors of the liver in mice.
Notes "Final report." "July 1985." Includes bibliographical references. "EPA-600/8-82-005F." Microfiche.
Place Published Research Triangle Park, NC :
Supplementary Notes See also PB84-155803.
Corporate Au Added Ent United States. Environmental Protection Agency. Environmental Criteria and Assessment Office.
PUB Date Free Form 1985.
NTIS Prices PC A12/MF A01
BIB Level m
Cataloging Source OCLC/T
OCLC Time Stamp 20011219190033
Language eng
Origin NTIS
OCLC Rec Leader 01188cam 2200265Ka 45170