||Role of Pharmacokinetic Modeling in Risk Assessment: Perchloroethylene (PCE) as an Example.
Chen, C. W. ;
Blancato, J. N. ;
||Environmental Protection Agency, Washington, DC. Carcinogen Assessment Group.
Perchloryl compounds ;
Risk assessment ;
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
||Available metabolic and pharmacokinetic data on perchloroethylene (PCE) are used as a basis for discussion of the use of such data in quantitative risk assessment. The emphasis is on methodologies for improving risk assessment rather than on the risk assessment of PCE per se. The data available on PCE are sufficient to independently construct a physiologically-based pharmacokinetic (PB-PK) model for each of the three species: humans, rats, and mice. The model is used to convert bioassay-administered doses into metabolized doses for dose-response calculation, to evaluate the effect of various exposure patterns on metabolized dose, and to compare inhalation risk estimates calculated on the basis of inhalation and gavage bioassay data. The advantages and limitations of using PB-PK models in risk assessment are addressed.
||Presented at the National Academy of Sciences Workshop on Pharmacokinetics and Risk Assessment, Washington, DC., October 1986.
|NTIS Title Notes
||Reprint: Role of Pharmacokinetic Modeling in Risk Assessment: Perchloroethylene (PCE) as an Example.
||PC A03/MF A01