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OLS Field Name OLS Field Data
Main Title Kinetics of In vivo Sister Chromatid Exchange Induction in Mouse Bone Marrow Cells in Ethylnitrosourea and Methylnitrosourea.
Author Charles, J. L. ; Jacobson-Kram, D. ; Condie, L. ; Borzelleca, J. F. ; Carchman, R. A. ;
CORP Author Virginia Commonwealth Univ., Richmond. Dept. of Pharmacology and Toxicology.;Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1986
Report Number EPA-R-808861; EPA/600/J-86/158;
Stock Number PB87-118501
Additional Subjects Bone marrow ; Toxicology ; Laboratory animals ; Mice ; Kinetics ; Reprints ; Sister chromatid exchange ; Urea/ethylnitroso ; Urea/methylnitroso
Holdings
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Status
NTIS  PB87-118501 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/21/1988
Collation 12p
Abstract Administration of ethylnitrosourea (ENU) (20, 25, 40, 50, and 60 mg/kg body weight) or methylnitrosourea (MNU) (25, 40, 50, 60, 75, and 80 mg/kg body weight) to male CD-1 mice 2 hours after subcutaneous implantation of 5-bromo-2'-deoxyurdine (BrdUrd) pellet (55 mg) resulted in a dose-dependent increase in sister chromatid exchanges (SCE) in bone marrow cells. Treatment with ENU (50 mg/kg body weight) at several time points prior to BrdUrd implantation resulted in a biphasic curve of SCE induction indicating at least two events that result in SCEs. Treatment with ENU at the time of BrdUrd implantation and post-BrdUrd reflected a similar mechanism apparent in the preBrdUrd curve. Treatment with MNU (50 mg/kg body weight) pre- and post-BrdUrd resulted in a linear monophasic curve of SCE induction in both the pre- and post-BrdUrd time periods. The overall MNU time-course curve resembled an inverted V function indicating the mechanism of SCE induction for ENU and MNU are different.
Supplementary Notes See also PB85-150845. Pub. in Toxicology and Applied Pharmacology 84, p56-65 Jun 86. Sponsored by Health Effects Research Lab., Research Triangle Park, NC.
NTIS Title Notes Journal article.
Title Annotations Reprint: Kinetics of In vivo Sister Chromatid Exchange Induction in Mouse Bone Marrow Cells in Ethylnitrosourea and Methylnitrosourea.
PUB Date Free Form c1986
Category Codes 57Y; 57Q
NTIS Prices PC A02/MF A01
Document Type NT
Cataloging Source NTIS/MT
Control Number 703717619
Origin NTIS
Type CAT