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OLS Field Name OLS Field Data
Main Title Comparative Gastrointestinal Enzyme Activity and Activation of the Promutagen 2,6-Dinitrotoluene in Male CD-1 Mice and Male Fischer 344 Rats.
Author Chadwick, R. W. ; George, S. E. ; Chang, J. ; Kohan, M. J. ; Dekker., J. P. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. ;North Carolina Univ. at Chapel Hill. ;Environmental Health Research and Testing, Inc., Research Triangle Park, NC.
Publisher c1990
Year Published 1990
Report Number EPA/600/J-90/169;
Stock Number PB91-115816
Additional Subjects Enzymes ; Gastrointestinal system ; Mutagens ; Toxicology ; Mice ; Rats ; Male ; Hepatuma ; In vitro analysis ; In vivo analysis ; Metabolism ; Bioassay ; Reprints ; Ditoluenes ; Species specificity ; Biotransformation ; Mutagenicity tests ; Carcinogenicity tests
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NTIS  PB91-115816 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 03/04/1991
Collation 9p
Abstract Comparative intestinal nitroreductase, azo reductase, beta-glucuronidase, dechlorinase, and dehydrochlorinase activities in young male Fischer 344 rats and young male CD-1 mice were measured in vitro while the comparative biotransformation of 2, 6-dinitrotoluene to mutagenic metabolites was determined in vivo. The mice, which exhibit a high spontaneous incidence of hepatomas, had markedly greater nitroreductase activity and metabolized significantly more 2, 6-dinitrotoluene to mutagenic metabolites than did Fischer 344 rats, which show a low incidence of liver tumors. Results of this study indicate that species differences in the incidence of hepatomas may be influenced by microbial flora and/or the biotransformation of xenobiotics in the G.I. tract. (Copyright (c) Elsevier Scientific Publishers Ireland, Ltd.)
Supplementary Notes Pub. in Cancer Letters, v52 n1 p13-19 Jun 90. Prepared in cooperation with North Carolina Univ. at Chapel Hill, and Environmental Health Research and Testing, Inc., Research Triangle Park, NC.
NTIS Title Notes Journal article.
Title Annotations Reprint: Comparative Gastrointestinal Enzyme Activity and Activation of the Promutagen 2,6-Dinitrotoluene in Male CD-1 Mice and Male Fischer 344 Rats.
Category Codes 57Y; 57F; 57B
NTIS Prices PC A02/MF A01
Primary Description 600/10
Document Type NT
Cataloging Source NTIS/MT
Control Number 101123259
Origin NTIS
Type CAT