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OLS Field Name OLS Field Data
Main Title Antagonism of Chlorobenzene-Induced Hepatotoxicity by Lindane.
Author Chadwick, R. W. ; Scotti, T. M. ; Copeland, M. F. ; Mole, M. L. ; Froehlich, R. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1984
Report Number EPA-600/J-84-032;
Stock Number PB84-206119
Additional Subjects Chlorine organic compounds ; Dosage ; Metabolism ; Reprints ; Lindane ; Cyclohexane/hexachloro ; Hepatotoxicity
Library Call Number Additional Info Location Last
NTIS  PB84-206119 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/23/1988
Collation 16p
Abstract In a 2x2 factorial designed experiment involving chlorobenzene and gamma-hexachlorocyclohexane (lindane), the hepatotoxicity induced by a challenge dose of chlorobenzene was altered by the pretreatments due to selective changes in various metabolic pathways. These changes resulted in either (1) a marginally significant decrease in hepatotoxicity (chlorobenzene-pretreatment); (2) significant reduction in both the incidence and severity of the lesions (lindane-pretreatment); or (3) absence of centrilobular hepatocellular necrosis in all but 1 of 12 rats where a minimal degree of necrosis was present (chlorobenzene + lindane-pretreatment).
Supplementary Notes Pub. in Pesticide Biochemistry and Physiology 21, p148-161 1984.
NTIS Title Notes Journal article.
Title Annotations Reprint: Antagonism of Chlorobenzene-Induced Hepatotoxicity by Lindane.
PUB Date Free Form 1984
Category Codes 6T; 6F; 57Y; 68E
NTIS Prices PC A02/MF A01
Document Type NT
Cataloging Source NTIS/MT
Control Number 424418650
Origin NTIS
Type CAT