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OLS Field Name OLS Field Data
Main Title 2,4,5-Trichlorophenoxyacetic Acid Influence on 2,6-Dinitrotoluene-Induced Urine Genotoxicity in Fisher 344 Rats: Effect on Gastrointestinal Microflora and Enzyme Activity.
Author George, S. E. ; Chadwick, R. W. ; Chang, J. J. ; Kohan, M. J. ; Allison, J. C. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. Neurotoxicology Div. ;North Carolina Univ. at Chapel Hill. ;Environmental Health Research and Testing, Inc., Research Triangle Park, NC.
Publisher c1992
Year Published 1992
Report Number EPA/600/J-92/250;
Stock Number PB92-206309
Additional Subjects Toxicity ; Mutagens ; Microbiology ; Gastrointestinal system ; Enzymes ; Rats ; Urine ; Dose-response relationships ; Metabolism ; Metabolic activation ; Reprints ; Trichlorophenoxyacetic acids ; Dinitrotoluenes
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NTIS  PB92-206309 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/01/1993
Collation 9p
Abstract 2,4,5-Trichlorophenoxyacetic acid and 2,6-dinitrotoluene are hazardous chemicals that have potential harmful effects. 2,6-DNT is recognized as a hepatoxicant while 2,4,5-T, a component in Agent Orange, is also suspect. 2,6-DNT requires both oxidative and reductive metabolism to elicit genotoxic effects. In order to determine what effect 2,4,5-T had on 2,6-DNT metabolism, intestinal enzymes, microbial populations, and urine mutagenicity were examined during 2,4,5-T treatment. Weanling Fischer 344 male rats were treated daily with 54.4 mg/kg 2,4,5-T by gavage for 4 weeks. 1,2, and 4 weeks after the initial dose, rats were administered (p.o.) 2,6-DNT (75 mg/kg) and urine was collected for 24 hours in metabolism cages. Azo reductase, nitroreductase, beta-glucuronidase, dechlorinase, and dehydrochlorinase activities were examined concurrently. Treatment of rats for one week reduced the transformation of 2,6-DNT to mutagenic urinary metabolites. This was accompanied by a decrease in the fecal anaerobic microorganisms. The elimination of Lactobacillus fermentum from the small intestine and cecum of treated animals accompanied a significant increase in oxygen tolerant lactobacilli and other unidentified aerobic microorganisms. (Copyright (c) 1992 by the Society of Toxicology.)
Supplementary Notes Pub. in Fundamental and Applied Toxicology, v18 n2 p240-246 Feb 92. Prepared in cooperation with North Carolina Univ. at Chapel Hill, and Environmental Health Research and Testing, Inc., Research Triangle Park, NC.
NTIS Title Notes Journal article.
Title Annotations Reprint: 2,4,5-Trichlorophenoxyacetic Acid Influence on 2,6-Dinitrotoluene-Induced Urine Genotoxicity in Fisher 344 Rats: Effect on Gastrointestinal Microflora and Enzyme Activity.
Category Codes 57Y; 57F; 57K
NTIS Prices PC A02/MF A01
Primary Description 600/10
Document Type NT
Cataloging Source NTIS/MT
Control Number 226923997
Origin NTIS
Type CAT