Main Title |
Effect of Dietary Lipid and Dimethyl Sulfoxide on Lindane Metabolism. |
Author |
Chadwick, R. W. ;
Simmons, W. S. ;
Bryden, C. C. ;
Chung, L. T. ;
Key., L. M. ;
|
CORP Author |
Health Effects Research Lab., Research Triangle Park, N.C. Environmental Toxicology Div. |
Year Published |
1976 |
Report Number |
EPA/600/J-77/092; |
Stock Number |
PB-278 597 |
Additional Subjects |
Pesticides ;
Chlorobenzenes ;
Lipids ;
Methyl sulfoxide ;
Metabolism ;
Dosage ;
Diet ;
Fatty acids ;
Rats ;
Bioassay ;
Laboratory animals ;
Food consumption ;
Growth ;
Excretion ;
Ribosomes ;
Toxicity ;
Insecticides ;
Lindane ;
Bioaccumulation
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB-278 597 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
21p |
Abstract |
Previous investigations have suggested that there is a requirement of dietary polyunsaturated fatty acids for full expression of microsomal enzyme induction. The conclusions in these studies were primarily based on in vitro enzyme activity, sleeping time recovery, or hepatic cytochrome P-450 content, measured 24 hr after treatment with an inducing agent. This study examines the influence of dietary lipids, containing different fatty acid compositions, on the storage and self-induction of lindane metabolism. Depressed food consumption and growth rate, an impaired metabolite excretion pattern, low specific microsomal phospholipid content and a decreased microsomal PC/PE ratio containing a reduced proportion of polyunsaturated fatty acids suggested that a toxic Lindane-DMSO-Dietary lipid interation had occurred. |
Supplementary Notes |
Also pub. as ISSN-0041-008X. |
Availability Notes |
Pub. in Toxicology and Applied Pharmacology 39, p391-410 1977. |
NTIS Title Notes |
Journal article. |
PUB Date Free Form |
19 Oct 76 |
Category Codes |
6T; 6A; 57Y; 57B; 68G; 68E |
NTIS Prices |
Not available NTIS |
Primary Description |
600/11 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
323737015 |
Origin |
NTIS |
Type |
CAT |