Main Title |
Estimating the Acute Toxicity of Narcotic Industrial Chemicals to Fathead Minnows. |
Author |
Veith, G. D. ;
Call, D. J. ;
Brooke, L. T. ;
|
CORP Author |
Environmental Research Lab.-Duluth, MN. ;Wisconsin Univ.-Superior. Center for Lake Superior Environmental Studies. |
Year Published |
1984 |
Report Number |
EPA-600/D-84-190; |
Stock Number |
PB84-224450 |
Additional Subjects |
Toxicology ;
Narcotics ;
Estimates ;
Fishes ;
Screening ;
Fathead minnows ;
Toxic substances ;
Water pollution effects(Animals)
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB84-224450 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
11p |
Abstract |
The overwhelming number of industrial chemicals either in commerce or in development precludes actual toxicity testing of each chemical and creates a need for initial screening techniques to focus efforts on those chemicals with the greatest potential for adverse environmental effects. One promising screening technique is the use of the structure-activity relationship to estimate aquatic toxicity from chemical structure. Using five major classes of industrial chemicals from the Toxic Substances Control Act (TSCA) inventory, this paper presents a structure-activity relationship between the 96-h LC50 with fathead minnows and the n-octanol/water partition coefficient which can be computed from structure. Common industrial alcohols, ketones, alkyl halides, ethers, and benzenes are shown to cause lethality by the same mode of action of narcosis. Consequently, a single bilinear equation can predict adequately the 96-h LC50 of all classes of industrial chemicals to fathead minnows. |
Supplementary Notes |
Prepared in cooperation with Wisconsin Univ.-Superior. Center for Lake Superior Environmental Studies. |
PUB Date Free Form |
Jul 84 |
Category Codes |
6T; 6F; 57Y; 68D |
NTIS Prices |
PC A02/MF A01 |
Primary Description |
600/03 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
430023315 |
Origin |
NTIS |
Type |
CAT |