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OLS Field Name OLS Field Data
Main Title Biochemical and Functional Alterations in Renal and Cardiac Development Resulting from Neonatal Methylmercury Treatment.
Author Slotkin, T. A. ; Pachman, S. ; Bartolome, J. ; Kavlock, R. J. ;
CORP Author Duke Univ. Medical Center, Durham, NC.;Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1985
Report Number EPA-R-811621; EPA/600/J-85/312;
Stock Number PB86-164043
Additional Subjects Toxicology ; Kidney ; Heart ; Rats ; Fetuses ; Laboratory animals ; Reprints ; Methylmercury
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NTIS  PB86-164043 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 06/21/1988
Collation 13p
Abstract Administration of methylmercury (1 or 2.5 mg/kg daily) to neonatal rats caused alterations in both cardiac and renal growth patterns. Heart weights were elevated in the preweaning period in association with hyperplasia (supranormal DNA content); after weaning, the cardiac overgrowth regressed and there was an eventual hypoplasia as evidenced by low DNA content in young adulthood. Renal overgrowth was more pronounced and persistent, but reflected a pure hypertrophy, with no changes in DNA. Despite the absence of apparent morphologic damage to the kidney, renal function was affected by neonatal methylmercury exposure, as assessed through basal clearance techniques. In the immediate period after beginning treatment, there was an impairment of renal function (elevated serum urea, creatinine and osmolality; increased fractional excretions of water, sodium and osmotic particles), with a return to normal by 10 days postnatally.
Supplementary Notes Pub. in Toxicology 36, n2-3 p231-241 Aug 85. Sponsored by Health Effects Research Lab., Research Triangle Park, NC.
NTIS Title Notes Journal article.
Title Annotations Reprint: Biochemical and Functional Alterations in Renal and Cardiac Development Resulting from Neonatal Methylmercury Treatment.
PUB Date Free Form c1985
Category Codes 6T; 57Y
NTIS Prices PC A02/MF A01
Primary Description 600/11
Document Type NT
Cataloging Source NTIS/MT
Control Number 612915783
Origin NTIS
Type CAT