||Toxicology of 1,1,2-Trichloroethane in the Mouse.
White, K. L. ;
Sanders, V. M. ;
Barnes, D. W. ;
Shopp, G. M. ;
Munson, A. E. ;
||Medical Coll. of Virginia, Richmond. Dept. of Pharmacology and Toxicology. ;East Carolina Univ., Greenville, NC.;Health Effects Research Lab., Research Triangle Park, NC.
Laboratory animals ;
Lethal dosage ;
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||1,1,2-Trichloroethane (TCE) was administered to male and female CD-1 mice to evaluate its effect on standard toxicological parameters. Following determination of the acute LD50 (378 mg/kg in males and 491 mg/kg in females), and a 14-day range-finding study, a 90-day drinking water study was performed in which the doses consumed were 4.4, 46, and 305 mg/kg for males and 3.9, 44, and 384 mg/kg for females. The liver was a target of TCE toxicity in both sexes as demonstrated by dose-dependent alterations in hepatic microsomal enzyme activities and serum enzyme levels. The erythroid element of the female mice was also affected, as indicated by significantly decreased hematocrit and hemoglobin levels.
||Pub. in Drug and Chemical Toxicology, v8 n5 p333-355 Oct 85. Prepared in cooperation with East Carolina Univ., Greenville, NC. Sponsored by Health Effects Research Lab., Research Triangle Park, NC.
|NTIS Title Notes
||Reprint: Toxicology of 1,1,2-Trichloroethane in the Mouse.
|PUB Date Free Form
||PC A02/MF A01