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OLS Field Name OLS Field Data
Main Title Toxicology of 1,1,2-Trichloroethane in the Mouse.
Author White, K. L. ; Sanders, V. M. ; Barnes, D. W. ; Shopp, G. M. ; Munson, A. E. ;
CORP Author Medical Coll. of Virginia, Richmond. Dept. of Pharmacology and Toxicology. ;East Carolina Univ., Greenville, NC.;Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1985
Report Number EPA-R-806481; EPA/600/J-85/415;
Stock Number PB86-214855
Additional Subjects Toxicology ; Bioassay ; Mice ; Laboratory animals ; Lethal dosage ; Liver ; Reprints ; Ethane/trichloro
Holdings
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NTIS  PB86-214855 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 06/21/1988
Collation 25p
Abstract 1,1,2-Trichloroethane (TCE) was administered to male and female CD-1 mice to evaluate its effect on standard toxicological parameters. Following determination of the acute LD50 (378 mg/kg in males and 491 mg/kg in females), and a 14-day range-finding study, a 90-day drinking water study was performed in which the doses consumed were 4.4, 46, and 305 mg/kg for males and 3.9, 44, and 384 mg/kg for females. The liver was a target of TCE toxicity in both sexes as demonstrated by dose-dependent alterations in hepatic microsomal enzyme activities and serum enzyme levels. The erythroid element of the female mice was also affected, as indicated by significantly decreased hematocrit and hemoglobin levels.
Supplementary Notes Pub. in Drug and Chemical Toxicology, v8 n5 p333-355 Oct 85. Prepared in cooperation with East Carolina Univ., Greenville, NC. Sponsored by Health Effects Research Lab., Research Triangle Park, NC.
NTIS Title Notes Journal article.
Title Annotations Reprint: Toxicology of 1,1,2-Trichloroethane in the Mouse.
PUB Date Free Form c1985
Category Codes 6T; 57Y
NTIS Prices PC A02/MF A01
Primary Description 600/11
Document Type NT
Cataloging Source NTIS/MT
Control Number 624112921
Origin NTIS
Type CAT