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OLS Field Name OLS Field Data
Main Title Subcellular Ions by X-ray Microanalysis for Evidence of Hepatotoxicity.
Author Millette, J. R. ; Allenspach, A. L. ; Clark, P. J. ;
CORP Author Health Effects Research Lab., Cincinnati, OH. ;Miami Univ., Oxford, OH. Dept. of Zoology.
Year Published 1985
Report Number EPA/600/D-85/093;
Stock Number PB85-218964
Additional Subjects Toxicology ; Hepatotoxicity ; Diagnostic agents ; Ion shifts
Library Call Number Additional Info Location Last
NTIS  PB85-218964 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 06/21/1988
Collation 7p
Abstract The hypothesis that the influx of extracellullar Ca2+ across a damaged plasma membrane is the final common pathway for chemically mediated cell death has stirred considerable controversy and continued interest in the study of subcellular ion shifts as sensitive indicators of hepatotoxicity caused by environmental pollutants. A number of studies have shown that increases in hepatic mitochondrial calcium result from the ingestion of carbon tetrachloride. Quantitative measurement of calcium in subcellular components was accomplished in early studies by using techniques involving whole tissue homogenation and fractionation by centrifugation. In the study x-ray microanalysis of quick-frozen liver tissue, cryo-sectioned for the electron microscope, provided an alternative approach to studying subcellular ion distribution.
Supplementary Notes Prepared in cooperation with Miami Univ., Oxford, OH. Dept. of Zoology.
PUB Date Free Form 1985
Category Codes 6E; 57D
NTIS Prices PC A02/MF A01
Primary Description 600/11
Document Type NT
Cataloging Source NTIS/MT
Control Number 524126749
Origin NTIS
Type CAT