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OLS Field Name OLS Field Data
Main Title Cytogenetic Studies of Mice Exposed to Styrene by Inhalation.
Author Kligerman, A. D. ; Allen, J. W. ; Bryant, M. F. ; Campbell, J. A. ; Collins, B. W. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. ;Environmental Health Research and Testing, Inc., Research Triangle Park, NC. ;National Inst. of Environmental Health Sciences, Research Triangle Park, NC.
Publisher 1992
Year Published 1992
Report Number EPA/600/J-93/403;
Stock Number PB93-236404
Additional Subjects Chromosome aberrations ; Styrene ; Mutagens ; Mice ; Respiration ; Sister chromatid exchange ; Spleen ; Lung ; Micronucleus tests ; Graphs(Charts) ; Reprints ;
Holdings
Library Call Number Additional Info Location Last
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Checkout
Status
NTIS  PB93-236404 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 11/22/1993
Collation 11p
Abstract The data for the in vivo genotoxicity of styrene (STY) are equivocal. To evaluate the clastogenicity and sister-chromatid exchange (SCE)-inducing potential of STY in vivo under carefully controlled conditions, B6C3F1 female mice were exposed by inhalation for 6 h/day for 14 consecutive days to either 0, 125, 250 or 500 ppm STY. One day after the final exposure, peripheral blood, spleen, and lungs were removed and cells were cultured for the analysis of micronucleus (MN) induction using the cytochalasin B-block method, chromosome breakage, and SCE induction. Peripheral blood smears were also made for scoring MN in erythrocytes. There was a significant concentration-related elevation of SCE frequency in lymphocytes from the spleen and the peripheral blood as well as in cells from the lung. However, no statistically significant concentration-related increases were found in the frequency of chromosome aberrations in the cultured splenocytes or lung cells, and no significant increases in MN frequencies were observed in binucleated splenocytes or normochromatic erythrocytes in peripheral blood smears. (Copyright (c) 1992 Elsevier Science Publishers B.V.)
Supplementary Notes Pub. in Mutation Research 280, n1 p35-43 Jul 92. Prepared in cooperation with Environmental Health Research and Testing, Inc., Research Triangle Park, NC., and National Inst. of Environmental Health Sciences, Research Triangle Park, NC.
NTIS Title Notes Journal article.
Title Annotations Reprint: Cytogenetic Studies of Mice Exposed to Styrene by Inhalation.
Category Codes 57Y; 57F
NTIS Prices PC A03/MF A01
Primary Description 600/10
Document Type NT
Cataloging Source NTIS/MT
Control Number 330925799
Origin NTIS
Type CAT