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OLS Field Name OLS Field Data
Main Title Results of 'In vitro' and 'In vivo' Genetic Toxicity Tests on Methyl Isocyanate.
Author Shelby, M. D. ; Allen, J. W. ; Caspary, W. J. ; Haworth, S. ; Ivett, J. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. Genetic Toxicology Div. ;National Inst. of Environmental Health Sciences, Research Triangle Park, NC. ;Microbiological Associates, Bethesda, MD. ;Environmental Health Research and Testing, Inc., Research Triangle Park, NC. ;Brookhaven National Lab., Upton, NY. Medical Dept.
Year Published 1987
Report Number EPA/600/J-87/230;
Stock Number PB88-171004
Additional Subjects Toxicology ; In vivo analysis ; In vitro analysis ; Reprints ; Genotoxicity ; Methyl isocyanate
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NTIS  PB88-171004 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 06/21/1988
Collation 7p
Abstract Methyl isocyanate (MIC) was tested for genetic toxicity in a variety of in vitro and in vivo assays. Negative results were obtained in the Salmonella/mammalian microsome assay using five bacterial strains in a preincubation protocol. The Drosophila sex-linked recessive lethal test also gave negative results in studies that involved three routes of administration: inhalation; feeding; and, injection. Positive results were obtained for three endpoints in cultured mammalian cells. Reproducible, dose-related increases in trifluorothymidine-resistant clones were induced in L5178Y mouse lymphoma cells, and the frequencies of both SCE and chromosomal aberrations increased in Chinese hamster ovary cells. These effects were independent of exogenous metabolism. In mice exposed to MIC by inhalation, cytogenetic analyses were carried out on bone marrow, blood, and lung cells. A single, 2-hr exposure to concentrations of 0, 3, 10, and 30 ppm MIC produced no evidence of chromosomal effects in the bone marrow, although significant cell cycle delay was observed.
Supplementary Notes Pub. in Environmental Health Perspectives, v72 p183-187 1987. Prepared in cooperation with National Inst. of Environmental Health Sciences, Research Triangle Park, NC., Microbiological Associates, Bethesda, MD., Environmental Health Research and Testing, Inc., Research Triangle Park, NC., and Brookhaven National Lab., Upton, NY. Medical Dept.
NTIS Title Notes Journal article.
Title Annotations Reprint: Results of 'In vitro' and 'In vivo' Genetic Toxicity Tests on Methyl Isocyanate.
PUB Date Free Form c1987
Category Codes 57Y; 57F
NTIS Prices PC A02/MF A01
Primary Description 600/11
Document Type NT
Cataloging Source NTIS/MT
Control Number 812722737
Origin NTIS
Type CAT