| Main Title |
CASE (Computer Automated Structure Evaluation) Study of In vitro Inhibition of Spareteine Monooxygenase. |
| Author |
Klopman, G. ;
Venegas, R. E. ;
|
| CORP Author |
Case Western Reserve Univ., Cleveland, OH. Dept. of Chemistry.;Health Effects Research Lab., Research Triangle Park, NC.;Office of Naval Research, Arlington, VA. |
| Publisher |
c1986 |
| Year Published |
1986 |
| Report Number |
EPA-R-812264; EPA/600/J-86/513; |
| Stock Number |
PB90-106394 |
| Additional Subjects |
Enzyme inhibitors ;
In vitro analysis ;
Tables(Data) ;
Reprints ;
Expert systems ;
Mixed function oxidases ;
Sparteine monooxygenase ;
Computer automated structure evaluation(CASE) ;
Structure-activity relationship
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB90-106394 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
21p |
| Abstract |
The Computer Automated Structure Evaluation program (CASE) has been used to analyze the in vitro inhibition of sparteine monooxygenase. A significant correlation between the Log10 P (1-octanol/water) of the 74 drugs studied and their inhibitory potency is observed. |
| Supplementary Notes |
Pub. in Jnl. of Acta Pharmaceutica (Yugoslavia) 36, p189-208 1986. Sponsored by Health Effects Research Lab., Research Triangle Park, NC., and Office of Naval Research, Arlington, VA. |
| NTIS Title Notes |
Journal article. |
| Title Annotations |
Reprint: CASE (Computer Automated Structure Evaluation) Study of In vitro Inhibition of Spareteine Monooxygenase. |
| Category Codes |
57F; 57B; 68G |
| NTIS Prices |
PC A03/MF A01 |
| Primary Description |
600/10 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
932619338 |
| Origin |
NTIS |
| Type |
CAT |
