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Main Title

Health assessment document for inorganic arsenic : final report.

Author

Jacobson-Kram, D. ; Mushak, P. ; Piscator, M. ; Sivulka, D. J. ; Chu, M.

CORP Author

United States. Environmental Protection Agency. Environmental Criteria and Assessment Office.

Publisher

U.S. Environmental Protection Agency, Office of Research and Development, Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office,

Year Published

1984

Report Number

EPA 600/8-83-021F

Stock Number

PB84-190891

OCLC Number

12940146

Subjects

Arsenic--Toxicology ; Carcinogens

Additional Subjects

Arsenic--Toxicology ; Carcinogens ; Public health ; Arsenic inorganic compounds ; Toxicology ; Environmental surveys ; Industrial wastes ; Smelting ; Biocides ; Glass industry ; Air pollution ; Absorption ; Potable water ; Oxidation reduction reactions ; Mutagens ; Metabolism ; Ingestion(Biology) ; Pathology ; Exposure ; Humans ; Animals ; Sources ; Ecology ; Risk ; Malignant neoplasms ; Water pollution ; Soils ; Foods ; Biotransformation ; Cancer

Internet Access

Description	Access URL
	https://nepis.epa.gov/Exe/ZyPDF.cgi?Dockey=30001B0W.PDF

Holdings

Library	Call Number	Additional Info	Location	Last Modified
EHBD	EPA-600/8-83-021F		CEMM/ACESD Library/Narragansett,RI	03/23/2007
EJED	EPA 600/8-83-021F		OCSPP Chemical Library/Washington,DC	01/26/2001
ELBD ARCHIVE	EPA 600-8-83-021F	Received from HQ	AWBERC Library/Cincinnati,OH	10/04/2023
ELBD	EPA 600-8-83-021F		AWBERC Library/Cincinnati,OH	01/28/1989
EMBD	EPA/600/8-83/021F		NRMRL/GWERD Library/Ada,OK	12/24/1992
ERAD	EPA 600/8-83-021F		Region 9 Library/San Francisco,CA	02/19/2013
ESAD	EPA 600-8-83-021F		Region 10 Library/Seattle,WA	07/29/2005
NTIS	PB84-190891	Some EPA libraries have a fiche copy filed under the call number shown.		07/26/2022

Collation

1 v. (various pagings) : ill. ; 28 cm.

Abstract

Inorganic arsenic, predominantly the tri- and pentavalent forms, is emitted to the environment primarily through smelting activity, biocide use and glass manufacturing. Monitoring data indicate a concentration of equal to or less than 0.1 microgram/cu m for most locations. Major routes of absorption of inorganic arsenic in the general population are inhalation and ingestion. Inhaled inorganic arsenic deposited in the lungs is eventually absorbed. Most ingested soluble inorganic arsenic is absorbed, whereas insoluble forms pass through the gastrointestinal tract with negligible absorption. Inorganic arsenic metabolism in man is complicated by biotransformation processes which include the methylation and oxidation-reduction interconversion of inorganic arsenic. Long-term accumulation of inorganic arsenic does not generally occur in physiologically active compartments in the body; renal clearance appears to be the major route of excretion of absorbed inorganic arsenic. Acute symptoms of inorganic arsenic poisoning include severe gastrointestinal damage, facial edema, cardiovascular reactions, peripheral nervous system disturbances, and hematopoietic system effects. General population concerns arising from long-term exposures to moderate levels of inorganic arsenic include respiratory tract cancer, skin cancer, non-cancerous skin lesions, peripheral neuropathological effects and cardiovascular effects. There appears to be a nutritional requirement for low levels of inorganic arsenic in certain experimental animals; however, this requirement has not yet been established in man.

Notes

"March 1984." "EPA-600/8-83-021F." Includes bibliographical references.

Place Published

Research Triangle Park, NC

Supplementary Notes