| Main Title |
Effects of d-Amphetamine on Behavioral and Autonomic Thermoregulation in Mice (Journal Version). |
| Author |
Bushnell, P. J. ;
Gordon, C. J. ;
|
| CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. |
| Publisher |
1987 |
| Year Published |
1987 |
| Report Number |
EPA/600/J-87/400; |
| Stock Number |
PB89-105647 |
| Additional Subjects |
Dextroamphetamine ;
Amphetamines ;
Body temperature regulation ;
Animal behavior ;
Locomotion ;
Temperature ;
Insisible water loss ;
Metabolism ;
Mice ;
Reprints ;
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB89-105647 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
7p |
| Abstract |
d-Amphetamine has well-known behavioral and sympathomimetic effects in rodents, but its effects on thermoregulation are not well characterized. d-Amphetamine was administered i.p. to mice at doses of 0.1 to 10.0 mg/kg. Locomotor activity and preferred ambient temperature (Ta) were measured for 60 min after injection in a linear temperature gradient, and metabolic rate (MR) and evaporative water loss (EWL) were measured in a metabolic chamber at ambient temperatures of either 20 deg C or 30 deg C. Colonic temperatures (Tc) were obtained 60 min after injection in all cases. Doses of d-amphetamine at 0.3 mg/kg and above reduced preferred Ta from the control value of 30 deg C to about 25 deg C. The behavioral and autonomic heat loss responses induced in mice by d-amphetamine suggest that its thermogenic action is detected by the animal at doses below those producing measurable thermogenesis and that appropriate effectors, from selection of a cool Ta to increasing EWL, are engaged in an orderly progression to maintain normothermia under all but the most challenging conditions. |
| Supplementary Notes |
Pub. in Pharmacology Biochemistry and Behavior, v27 p431-435 1987. |
| NTIS Title Notes |
Journal article. |
| Title Annotations |
Reprint: Effects of d-Amphetamine on Behavioral and Autonomic Thermoregulation in Mice (Journal Version). |
| Category Codes |
57Q; 57S; 57Z |
| NTIS Prices |
PC A02/MF A01 |
| Primary Description |
600/11 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
833027511 |
| Origin |
NTIS |
| Type |
CAT |
