| Main Title |
Study of the chemical and behavioral toxicology of substitute chemicals in microtine rodents / |
| Author |
Cholakis, J. M., ;
Wond, Laurence C. K. ;
Lee, Cheng-Chun
|
| Other Authors |
|
| CORP Author |
Midwest Research Institute (Kansas City, Mo.); Pacific Environmental Research Laboratory.; Midwest Research Inst., Kansas City, MO.; Corvallis Environmental Research Lab., OR. |
| Publisher |
U.S. Corvallis Environmental Research Laboratory ; |
| Year Published |
1978 |
| Report Number |
EPA-600/3-78-082; MRI 4298-B; EPA-68-01-4195; PB288416 |
| Stock Number |
PB-288 416 |
| OCLC Number |
04506711 |
| Subjects |
Pesticides and wildlife ;
Pesticides--Toxicology ;
Microtus
|
| Additional Subjects |
Pesticides and wildlife ;
Pesticides--Toxicology ;
Microtus ;
Insecticides ;
Herbicides ;
Behavior ;
Rodents ;
Lethal dosage ;
Diets ;
Ingestion(Biology) ;
Laboratory animals ;
Experimental data ;
Dose rate ;
Sensitivity ;
Females ;
Males ;
Concentration(Composition) ;
Chlorine organic compounds ;
Dieldrin ;
Toxicity ;
Tables(Data) ;
Microtus ochrogaster ;
Animal models ;
Toxic substances ;
Voles ;
D 24 herbicide ;
Acetic acid/dichlorophenoxy ;
Phosphorothioic acid/0-0-(dimethyl-ester)-0-(nitrophenylester) ;
Benzene/nitro-pentachloro ;
Acetic acid/trichlorophenoxy ;
T2-4-5 herbicide ;
Propanil ;
Propionanilide/dichloro ;
Simazine ;
Triazine/bis(ethylamino)-chloro ;
Environmental chemical substitutes ;
Microtus canicaudus ;
Microtus pennsylvanicus ;
Microtus montanus ;
Dimethanonaphthalenes ;
PCNB fungicide ;
Methyl parathion ;
Benzene/hexachloro ;
Toluidine/trifluoro-dinitro-N-N-dipropyl
|
| Internet Access |
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| EJBD ARCHIVE |
EPA 600/3-78-082 |
|
Headquarters Library/Washington,DC |
03/04/2015 |
| EJED |
EPA-600/3-78-082 |
|
OCSPP Chemical Library/Washington,DC |
03/13/1999 |
| EKBD |
EPA-600/3-78-082 |
|
Research Triangle Park Library/RTP, NC |
07/18/2003 |
| ESAD |
EPA 600-3-78-082 |
|
Region 10 Library/Seattle,WA |
08/22/2017 |
| ESBD |
EPA-600-3-78-082 |
|
CPHEA/PESD Library/Corvallis,OR |
09/05/2017 |
| NTIS |
PB-288 416 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
vi, 54 pages ; 28 cm |
| Abstract |
Acute oral LD50 and 30-day dietary subacute LC50 studies of 10 selected pesticides were evaluated in microtine rodents. As a means to developing new animal model systems, four species of microtine rodents including Microtus ochrogaster (MO), Microtus canicaudus (MC), Microtus pennsylvanicus (MP) and Microtus montanus (MM) voles were used. The acute LD50 (median lethal dose in mg/kg) in all four species and the subacute LC50 (median lethal concentration in ppm) in MO and MC voles were computed using probit analysis. The data from both the acute and the 30-day subacute studies revealed that MC voles were approximately twice as sensitive to these pesticides as MO voles. Based on the acute studies, the overall order of pesticide toxicity was as follows: parathion > methyl parathion > dieldrin > 2,4-D > 2,4,5-T > simazine propanil = PCNB = HCB = trifluralin. The general order of species sensitivity was as follows: MC> MP> MO>MM. No apparent sex differences were observed in MP, MO or MM voles. In MC voles, the female appeared to be two- to three-fold more sensitive to methyl parathion than the male. Based on the 30-day subacute LC50 studies, the overall order of pesticide toxicity is as follows: dieldrin> parathion> methyl parathion> HCB> 2,4,5-T> PCNS> propanil. Based on LD50 values the laboratory rodents appear to be more susceptible to 2,4-D, dieldrin, methyl parathion, parathion, propanil, and 2,4,5-T, equally susceptible to HCB, PCNB, and trifluralin, and less susceptible to simazine than the MC voles. |
| Notes |
Prepared for the U.S. Environmental Protection Agency, Office of Research and Development, Corvallis Environmental Research Laboratory, under Contract no. 68-01-4915. Includes bibliographical references (pages 19-20). |
| Place Published |
Corvallis, Or. Springfield, Va. |
| Access Notes |
Also available via the World Wide Web. |
| Corporate Au Added Ent |
Corvallis Environmental Research Laboratory, |
| Title Ser Add Ent |
Research reporting series. Ecological research ; EPA-600/3-78-082. |
| Alternate Title |
Microtine rodents. |
| PUB Date Free Form |
1978 |
| Series Title Traced |
Ecological research series ; EPA-600/3-78-082 |
| Series Title Untraced |
Ecological research series ; EPA-600/3-78-082 |
| NTIS Prices |
PC A04/MF A01 |
| BIB Level |
m |
| Medium |
unmediated |
| Content |
text |
| Carrier |
volume |
| Cataloging Source |
OCLC/T |
| Merged OCLC records |
4457478; 1225702772 |
| OCLC Time Stamp |
20170830061528 |
| Language |
eng |
| SUDOCS Number |
EP 1.23:600/3-78-082 |
| Origin |
OCLC |
| Type |
MERGE |
| OCLC Rec Leader |
02718cam 2200613Ii 45010 |
