| Main Title |
Hepatitis Delta Virus [electronic resource] / |
| Type |
EBOOK |
| Author |
Casey, John L.
|
| Publisher |
Springer Berlin Heidelberg, |
| Year Published |
2006 |
| Call Number |
QR355-502 |
| ISBN |
9783540298021 |
| Subjects |
Medicine ;
Medical virology
|
| Internet Access |
|
| Collation |
XI, 228 p. 25 illus. online resource. |
| Notes |
Due to license restrictions, this resource is available to EPA employees and authorized contractors only |
| Contents Notes |
Structure and Replication of Hepatitis Delta Virus RNA -- HDV RNA Replication: Ancient Relic or Primer? -- HDV Ribozymes -- RNA Editing in Hepatitis Delta Virus -- Post-translational Modification of Delta Antigen of Hepatitis D Virus -- The Role of the HBV Envelope Proteins in the HDV Replication Cycle -- Prenylation of HDAg and Antiviral Drug Development -- Hepatitis Delta Virus Genetic Variability: From Genotypes I, II, III to Eight Major Clades? -- Functional and Clinical Significance of Hepatitis D Virus Genotype II Infection -- Immunology of HDV Infection -- The Woodchuck Model of HDV Infection. Since its discovery nearly 30 years ago, hepatitis delta virus (HDV) has continued to surprise and fascinate. At 1,680 nucleotides the HDV genome is the smallest known to infect man. It is unique among animal viruses, the closest known relatives being plant viroids. To compensate for its limited protein coding capacity, HDV relies heavily on host functions and on structural features of its circular RNA genome. HDV infection depends on hepatitis B virus as a helper, and increases the severity of liver disease caused by HBV alone. There is currently neither an effective HDV vaccine nor a generally accepted useful therapy for HDV infection. This volume encompasses recent developments in HDV research, from molecular virology to genetics to experimental investigation of new therapeutic and vaccine candidates. |
| Place Published |
Berlin, Heidelberg |
| Corporate Au Added Ent |
SpringerLink (Online service) |
| Title Ser Add Ent |
Current Topics in Microbiology and Immunology, 307 |
| Host Item Entry |
Springer eBooks |
| PUB Date Free Form |
2006 |
| Series Title Untraced |
Current Topics in Microbiology and Immunology, 307 |
| BIB Level |
m |
| Medium |
computer |
| Content |
text |
| Carrier |
online resource |
| Cataloging Source |
OCLC/T |
| OCLC Time Stamp |
20131217142310 |
| Language |
eng |
| Origin |
SPRINGER |
| Type |
EBOOK |
| OCLC Rec Leader |
02817nam a22004215i 45 |
