| Main Title |
Replicating Vaccines A New Generation / [electronic resource] : |
| Type |
EBOOK |
| Author |
Dormitzer, Philip R.
|
| Other Authors |
|
| Publisher |
Springer Basel, |
| Year Published |
2011 |
| Call Number |
QR46 |
| ISBN |
9783034602778 |
| Subjects |
Medicine ;
Immunology ;
Microbiology ;
Vaccines ;
Medical virology
|
| Internet Access |
|
| Edition |
First. |
| Collation |
XIII, 447 p. online resource. |
| Notes |
Due to license restrictions, this resource is available to EPA employees and authorized contractors only |
| Contents Notes |
SECTION 1: Today's Live Attenuated Vaccines -- Live Vaccines and their Role in Modern Vaccinology -- Live Attenuated Vaccines: Influenza, Rotavirus and Varicella Zoster -- Classical Live Viral Vaccines -- SECTION 2: Genetically Attenuated Micro-Organisms as Vaccines -- Recombinant Live Vaccines to Protect Against the Severe Acute Respiratory Syndrome Coronavirus -- Live Attenuated Shigella Vaccines. Is encouraging good enough? -- New generation BCG vaccines -- SECTION 3: Manipulating Host-Pathogen Interactions to Make Vaccines -- Basic Science Paves the Way to Novel Safe and Effective Pestivirus Vaccines -- Live Attenuated Influenza Virus Vaccines: NS1 Truncation as an Approach to Virus Attenuation Approaches -- An Attenuated Herpes implex Virus 1 Live Virus Vaccine Candidate that is Replication Competent but Defective in Epithelial Cell to Cell and Neuronal Spread -- RSV Deletion Mutant - Innate Immunity -- Live Attenuated Cholera Vaccines: Flagella and Reactogenicity -- SECTION 4: New Types of Replicating Vaccines -- Replication-defective Herpes simplex Virus Mutant Strains as Genital Herpes Vaccines and Vaccine Vectors -- Nucleic Acid-Based Infectious and Pseudo-Infectious Flavivirus Vaccines -- Application of Cleavage Activation Mutants of Influenza Virus as Live Vaccines -- Alphavirus Particle-based Vaccine Vectors -- Recombinant, Chimeric, Live, Attenuated Vaccines against Flaviviruses and Alphaviruses. Technological advances, together with a better understanding of the molecular biology of infectious microorganisms, are creating exciting possibilities for a new generation of replicating vaccines. Historically, live vaccines have been either directly derived from a natural source or attenuated by empirical approaches using serial passages and host cell adaptation. Currently, we are witnessing a quantum leap in our technological capabilities to specifically modify the genetic make-up of viruses and bacteria, making it possible to generate improved live vaccines and to develop completely new types of replicating vaccines, such as vectored vaccines, single-round infectious vaccines and replicon vaccines. This book highlights some of the most exciting recent developments towards a new generation of replicating vaccines. |
| Place Published |
Basel |
| Corporate Au Added Ent |
SpringerLink (Online service) |
| Title Ser Add Ent |
Birkhäuser Advances in Infectious Diseases |
| Host Item Entry |
Springer eBooks |
| PUB Date Free Form |
2011 |
| Series Title Untraced |
Birkhäuser Advances in Infectious Diseases |
| BIB Level |
m |
| Medium |
computer |
| Content |
text |
| Carrier |
online resource |
| Cataloging Source |
OCLC/T |
| OCLC Time Stamp |
20130725202653 |
| Language |
eng |
| Origin |
SPRINGER |
| Type |
EBOOK |
| OCLC Rec Leader |
03937nam a22005295i 45 |
