| Main Title |
Pharmacokinetics and Metabolism of Benzo(A)Pyrene and Dimethylbenzanthracene in Rainbow Trout (Salmo Quairdneri) (Final Report) with Cover Letter dated 05/26/1988. |
| CORP Author |
New York Univ. Medical Center, NY. ;American Petroleum Inst., Washington, DC.;Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Publisher |
6 May 1988 |
| Year Published |
1988 |
| Report Number |
FYI-AX-0688-0369; |
| Stock Number |
OTS-0000369-3 |
| Additional Subjects |
Pharmacokinetics ;
Clinical medicine ;
Benzo(a)pyrene ;
Dimethylbenzanthracene ;
Rainbow trout ;
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS-0000369-3 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
117p |
| Abstract |
Rainbow trout were given Benzo(a)pyrene and 7, 12-dimethylbenz(a)-anthracene by gavage. Experiments were designed to determine assimilation, disposition and elimination of these PAH after single doses and multiple doses. Liver, gall bladder and alimentary tissues were extracted to measure parent compounds and metbolites in the tissues. Separate studies were conducted to determine binding of BaP and DMBA metabolites to DNA and the effects of cooking on the concentrations of the PAHs in the edible flesh. Trout assimilated BaP and DMBA rapidly. Initial disposition of the PAHs was to the muscle tissue followed by redistribution within 6 hr such that most of BaP and DMBA was in the liver-gall bladder compartment. Half-times for assimilation and elimination of the compounds were similar, resulting in low levels of accumulation of PAH from a single dose. Most of the BaP and DMBA in the liver-gall bladder compartment 72 hr after administration of a single dose were in the form of metabolites. |
| Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Prepared in cooperation with American Petroleum Inst., Washington, DC. |
| Availability Notes |
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| Category Codes |
57Q |
| NTIS Prices |
PC A07/MF A02 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
010001260 |
| Origin |
NTIS |
| Type |
CAT |
