Main Title |
Triphenyl Phosphite: In vivo and In vitro Inhibition of Rat Neurotoxic Esterase (Journal Version). |
Author |
Padilla, S. S. ;
Grizzle, T. B. ;
Lyerly, D. ;
|
CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. ;Northrop Services, Inc., Research Triangle Park, NC. |
Publisher |
c1987 |
Year Published |
1987 |
Report Number |
EPA/600/J-87/384; |
Stock Number |
PB89-106819 |
Additional Subjects |
Toxic substances ;
Toxicity ;
Carboxylic ester hydrolases ;
Spinal cord ;
Brain ;
Laboratory animals ;
Enzyme inhibitors ;
Phosphorus organic compounds ;
Nerve degeneration ;
Reprints ;
Triphenyl phosphite ;
Neurotoxic esterase ;
Phosphorous acid/triphenyl ester
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB89-106819 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
9p |
Abstract |
Organophosphorus compounds which, after acute administration, inhibit neurotoxic esterase (NTE) by > or = 65% and undergo a subsequent 'aging' reaction, produce a delayed neuropathy characterized by degeneration of large and long nerve fibers. The present studies examine in detail the NTE-inhibiting properties of triphenyl phosphite (TPP), a plasticizer which produces ataxia and degeneration of the spinal cord in animals. A neurotoxic dosing regimen (1184 mg/kg/week, sc, for 2 weeks) inhibited both brain and spinal cord NTE (< or = 40%) only marginally 4 and 48 hr postdosing. By contrast, TPP was shown in vitro to be a potent inhibitor of rat brain NTE relative to Mipafox or diisopropyl phosphorofluoridate. Preincubation of 10 micromolar TPP in buffer (37 deg C) resulted in a time-dependent loss of TPP's ability to inhibit NTE. In summary, TPP is a powerful NTE inhibitor in vitro, but only a marginal NTE inhibitor after in vivo administration. These results raise questions as to the causal events mediating TPP-induced neuropathy in the rat. (Copyright (c) 1987 Academic Press, Inc.) |
Supplementary Notes |
Pub. in Toxicology and Applied Pharmacology, v87 p249-256 1987. Prepared in cooperation with Northrop Services, Inc., Research Triangle Park, NC. |
NTIS Title Notes |
Journal article. |
Title Annotations |
Reprint: Triphenyl Phosphite: In vivo and In vitro Inhibition of Rat Neurotoxic Esterase (Journal Version). |
Category Codes |
57Y; 57B; 57U; 44G; 68G |
NTIS Prices |
Not available NTIS |
Primary Description |
600/11 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
833027842 |
Origin |
NTIS |
Type |
CAT |