Full Record Display for the EPA National Library Catalog

RECORD NUMBER: 2 OF 7

Main Title Letter from Dow Corning Corporation to USEPA Submitting Substantial Risk Information on Trimethoxysilane with Cover Letter dated 06/12/80.
CORP Author Dow Chemical Co., Midland, MI.;Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Publisher 17 Jun 1980
Year Published 1980
Report Number 8HEQ-0680-0347;
Stock Number OTS-0204852
Additional Subjects Toxicity ; Clinical medicine ; Inhalation ; Rats ; Exposure ; Dosage ; Pathology ; Eye ; Skin(Anatomy) ; Response(Biology) ; Body weight ; Blood ; USE EPA ; Laboratory tests ; Trimethoxysilane ; Dow Corning Corporation
Holdings
Library Call Number Additional Info Location Last
Modified
Checkout
Status
NTIS  OTS-0204852 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 187p
Abstract The Dow Corning Corporation has submitted the summarized preliminary results from a 28-day inhalation study of trimethoxysilane (CAS No. 2487-90-3) in male and female rats. Exposures to the chemical at chamber concentrations of 0.5, 5.0, and 10.0 parts per million were reportedly carried out for five (5) days per week, seven (7) hours per day for four (4) weeks. At the highest dose, 60% of the animals had died after 2-3 weeks of exposure. High dose exposure was terminated by the 21st day and the remaining rats sacrificed in order to provide clinical and pathological data. At the mid-dose, 40% of the animals had died by the end of the fourth week. Neither the control (air) group nor the low-dose group experienced any mortality in the experiment. The submitter reports that significant decreases in both food consumption and body weight and general weakness with moderate to severe lung congestion were observed in the high and mid-dose animals of both sexes. Significant deviations from control values were also found in hematological parameters (males and females; mid and high dose) and blood biochemical parameters (females; high dose). Subacute to chronic bronchitis and bronchiolitis were observed in all rats (male and female) exposed to trimethoxysilane at 5 and 10 ppm; similar lesions were reportedly not found in the 0.5 ppm dose group or in the control group.
Supplementary Notes The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Prepared in cooperation with American Petroleum Inst., Washington, DC.
Availability Notes Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA.
Category Codes 57Y; 57O
NTIS Prices PC A10/MF A02
Document Type NT
Cataloging Source NTIS/MT
Control Number 009400240
Origin NTIS
Type CAT