||Interlaboratory Comparison of Thermospray and Particle Beam Liquid Chromatography/Mass Spectrometry Interfaces: Evaluation of a Chlorinated Phenoxy Acid Herbicide Liquid Chromatography/Mass Spectrometry Analysis Method.
Jones, T. L. ;
Betowski, L. D. ;
Lesnik, B. ;
Chiang, T. C. ;
Teberg, J. E. ;
||Lockheed Engineering and Sciences Co., Inc., Las Vegas, NV. ;Department of Energy, Washington, DC. Lab. Management Div.;Environmental Monitoring Systems Lab., Las Vegas, NV.
Chemical analysis ;
Liquid chromatography ;
Mass spectroscopy ;
Interlaboratory comparisons ;
Chlorine organic compounds ;
Performance evaluation ;
Experimental design ;
Thermospray liquid chromatography ;
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||Seven laboratories participated in an interlaboratory evaluation of a liquid chromatography/mass spectrometry (LC/MS) method for the analysis of 10 chlorinated phenoxy acid herbicides. The focus of the evaluation was to test the intercomparability of LC/MS data obtained from two types of LC/MS interfaces (i.e., thermospray (TS) and particle beam (PB)). Eight simulated sample extracts were sent to each laboratory for LC/MS analysis. There were statistically significant differences between interfaces in the quantitative data for all analytes except 2-(2,4,5-trichlorophenoxy) propanoic acid (silvex). Particle beam exhibited a high positive bias and a low relative standard deviation at the highest sample extract concentration range, 500 micrograms/mL, while TS showed a low bias and a low relative standard deviation at the lowest sample extract concentration range, 5 micrograms/mL. Another factor of the study was to look for any performance differences between interfaces of the same type, but differing manufacturers. A statistical difference was observed, between PB interfaces, for 2-(1-methylpropyl)-4,6-dinitrophenol (dinoseb). (Copyright (c) 1991 by the American Chemical Society.)
||Pub. in Environmental Science and Technology, v25 n11 1991. See also PB88-215306. Prepared in cooperation with Department of Energy, Washington, DC. Lab. Management Div. Sponsored by Environmental Monitoring Systems Lab., Las Vegas, NV.
|NTIS Title Notes
||Reprint: Interlaboratory Comparison of Thermospray and Particle Beam Liquid Chromatography/Mass Spectrometry Interfaces: Evaluation of a Chlorinated Phenoxy Acid Herbicide Liquid Chromatography/Mass Spectrometry Analysis Method.
||PC A02/MF A01