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OLS Field Name OLS Field Data
Main Title Retinoidal Benzoic Acids (Arotenoids) and Other Retinoids Inhibit In vitro Transformation of Epithelial Cells.
Author Mass., M. J. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC.
Publisher c1990
Year Published 1990
Report Number EPA/600/J-90/077;
Stock Number PB90-245499
Additional Subjects Trachea ; Epithelium ; In vitro analysis ; Carcinogens ; Cells(Biology) ; Reprints ; Retinoids ; Neoplastic cell transformation ; Methylnitronitrosoguanidine ; Dose-response relationships ; Cell survival
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NTIS  PB90-245499 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 12/03/1990
Collation 7p
Abstract Five retinoids were evaluated for their ability to inhibit N-methyl-N'-nitro-N-nitrosoguanidine (MNNG)-induced transformation of primary rat tracheal epithelial (RTE) cells in culture at concentrations that did not affect cell survival. Two retinoidal benzoic acids (arotenoids), Ro 13-6298 and Ro 13-7410, suppressed the transformation frequency by 80-90% at 330 pM whereas at 330 pM retinoic acid suppressed the transformation frequency by 50%. In addition, retinol and retinyl acetate were tested at 33 nM and found to be much less effective than RA at this concentration. In studies with all retinoids, the spontaneously occurring transformed epithelial foci were suppressed from arising by a greater extent than were those that arose in response to carcinogen treatment. A biological difference between carcinogen-induced and spontaneously arising foci is suggested by this result.
Supplementary Notes Pub. in Jnl. of Anticancer Research, v10 p241-246 Jan 90.
NTIS Title Notes Journal article.
Title Annotations Reprint: Retinoidal Benzoic Acids (Arotenoids) and Other Retinoids Inhibit In vitro Transformation of Epithelial Cells.
Category Codes 57Q; 57Y; 57F
NTIS Prices PC A02/MF A01
Primary Description 600/10
Document Type NT
Cataloging Source NTIS/MT
Control Number 024228051
Origin NTIS
Type CAT