||Report of an Animal Experiment to Analyze Silica Gel Dust by Intratracheal and in Traperitoneal Injections in a Rat with Cover Letter dated 07/24/80.
||MCB Manufacturing Chemists, Inc., Cincinnati, OH.;Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
||30 Jul 1980
Silica gel ;
Body weight ;
Laboratory animals ;
Lymph nodes ;
Intramuscular injections ;
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||The reaction and behavior of rats when injected with silica gel dust are being tested, as opposed to the reaction and behavior of a pure quartz dust application. For the experiment we used female Wistar rats weighing 250g. The animals were nourished with Altronium-R and water ad libitum. The dust originated from a fine dust sample from E. Merck, Darmstadt. The quartz was Doerentruper Nr. 12, sedimented to less than 3 micrograms. Both were suspended in a sterile 0.9 salt solution. The intratrachea injection contained a dust dose of 30mg/animal in 0.5ml salt solution-the intraperitoneum injections 50mg/animal in 1.0ml salt solution.
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||PC A04/MF A01