| Main Title |
Transgenic animal mutagenicity assays / |
| Other Authors |
|
| Publisher |
World Health Organization, |
| Year Published |
2006 |
| Report Number |
EHC 233 |
| OCLC Number |
77516640 |
| ISBN |
9789241572330; 9241572337; 9789241572337 |
| Subjects |
Mutagenicity testing ;
Transgenic animals ;
Genetic toxicology ;
Health risk assessment ;
Mutagenicity Tests ;
Animals, Genetically Modified--genetics ;
Mutagens--toxicity ;
Organismes génétiquement modifiš ;
Mutations provoques ;
Toxicité ;
Mutageniteit ;
Transgene organismen ;
Mutagãenese (testes) ;
Camundongos (genética) ;
Mediðcäao de risco ;
Exposiðcäao ambiental ;
Transgene Tiere ;
Versuchstiere ;
Mutagenitätstest ;
Camundongos (genâetica) ;
Mutagenitèatstest ;
Mutag enese (testes)--larpcal ;
Camundongos (genetica)--larpcal ;
Medi c ao de risco--larpcal ;
Exposi c ao ambiental--larpcal
|
| Internet Access |
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| EJEM |
RA565.A1E58 no. 233 |
|
OCSPP Chemical Library/Washington,DC |
01/19/2009 |
| ELBM |
RA565.A1E63 2006 no.233 |
|
AWBERC Library/Cincinnati,OH |
08/19/2013 |
|
| Collation |
xxv, 298 pages : illustrations. |
| Notes |
"Published under the joint sponsorship of the United Nations Environment Programme, the International Labour Organisation, and the World Health Organization, and produced within the framework of the Inter-Organization Programme for the Sound Management of Chemicals." "International Programme on Chemical Safety"--Cover. Includes bibliographical references (pages 179-214). |
| Contents Notes |
Part 1. Overview of genotoxicity testing and transgenic animal mutagenicity systems -- Overview of genotoxicity testing -- Constructions/production of transgenic animals using as examples the lacI and lacZ mutation models -- The transgenic mutagenicity assay-methodology using as examples lacI and lacZ mutation models -- Further transgenic mutagenicity assays -- Parameters and criteria for valid experimental design -- Part 2. Comparison of the lacI model and the lacZ model with conventional test systems -- Introduction to part 2 -- Comparison of the Muta (superscript TM) mouse and Big Blueª assays -- Transgenic assays-comparison with other assays -- Transgenic assays and carcinogenicity testing -- Part 3. Applications of transgenic animal mutagenicity studies -- Mutation frequencies and sequencing data and applications of this information in mechanistic studies -- Part 4. Evaluation, conclusions and recommendations -- Evaluation of the transgenic animal mutagenicity assays based on this review of the current literature -- Conclusions -- Recommendations. This document provides an introduction to the field of transgenic mutagenicity assays and assesses the possible role of these assays in toxicology testing and mechanistic research. Part I gives a short overview of in vivo genotoxicity testing. Part II gives an overview of the data produced by various assays. Part III discusses the use of the assays in research. Part IV evaluates the role and potential added value of transgenic mutation assays in toxicology and risk assessment. This document is directed at toxicologists, research scientists and risk assessors.--Publisher's description. |
| Place Published |
Geneva |
| Access Notes |
Also available online.; System requirements: Adobe Acrobat Reader.; Mode of access: World Wide Web. |
| Corporate Au Added Ent |
United Nations Environment Programme.; International Labour Organisation.; World Health Organization.; Inter-Organization Programme for the Sound Management of Chemicals.; International Program on Chemical Safety. |
| Title Ser Add Ent |
Environmental health criteria, 233. |
| PUB Date Free Form |
2006 |
| Series Title Traced |
Environmental health criteria, 233 |
| Series Title Untraced |
Environmental health criteria, 233 |
| BIB Level |
m |
| Cataloging Source |
OCLC/T |
| Merged OCLC records |
77549153; 968204419; 971014842; 977963876; 988628026; 989342623; 1017312891; 1050577390 |
| OCLC Time Stamp |
20130815160815 |
| Language |
eng |
| Origin |
OCLC |
| Type |
CAT |
| OCLC Rec Leader |
04308cam 2200913 a 45020 |
