| Main Title |
Behavioral Toxicity of Trialkyltin Compounds: A Review. |
| Author |
Reiter, L. W. ;
Ruppert, P. H. ;
|
| CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. |
| Year Published |
1983 |
| Report Number |
EPA-600/D-84-012; |
| Stock Number |
PB84-130426 |
| Additional Subjects |
Toxicity ;
Tin organic compounds ;
Behavior ;
Reviews ;
Laboratory animals ;
Exposure ;
Dosage ;
Neurology ;
Humans ;
Toxic diseases ;
Public health ;
Industrial hygiene ;
Toxic substances ;
Air pollution effects(Humans) ;
Occupational safety and health ;
Tin/triethyl ;
Tin/trimethyl ;
Neurotoxicity
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB84-130426 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
22p |
| Abstract |
Triethyltin (TET) and trimethyltin (TMT) are neurotoxic organotin compounds which produce different patterns of toxicity in adult animals. Exposure to TET produces behavioral toxicity (decreased motor activity, grip strength, operant response rate and startle response amplitude) which reflects impaired neuromotor function. These deficits are consistent with the reported myelin vacuolation and cerebral edema produced by TET, and with its direct effects on muscle. Exposure to TMT produces both hyperactivity and impaired learning and performance. These impairments are consistent with reported neuronal cell death produced by TMT, particularly in limbic system structures. While the behavioral deficits produced by repeated exposure to TET are reversible when dosing is terminated, the behavioral impairment produced by a single exposure TMT appears to be irreversible. |
| PUB Date Free Form |
1983 |
| Category Codes |
6T; 6E; 6J; 68G; 68A; 57Y; 57U; 41I |
| NTIS Prices |
PC A02/MF A01 |
| Primary Description |
600/11 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
406249862 |
| Origin |
NTIS |
| Type |
CAT |
