| Main Title |
Toxicity of Fentin Hydroxide to Rats. |
| Author |
Gaines, Thomas B. ;
Kimbrough., Renate D. ;
|
| CORP Author |
National Communicable Disease Center, Atlanta, Ga. |
| Year Published |
1967 |
| Stock Number |
PB-280 838 |
| Additional Subjects |
Toxicology ;
Ingestion(Biology) ;
Diets ;
Fertility ;
Males ;
Females ;
Rats ;
Laboratory animals ;
Concentration(Composition) ;
Lethal dosage ;
Bioassay ;
Pathology ;
Tables(Data) ;
Tin organic compounds ;
Tin/hydroxy-triphenyl ;
Reprints ;
Chemisterilants ;
Toxic substances
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB-280 838 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
7p |
| Abstract |
Fentin hydroxide (triphenyl tin hydroxide) was given in the diet to rats at the rate of 400 ppm. This amount reduced the food consumption and, within 7-34 days, caused death from starvation and hemorrhage in all tested rats. Dietary levels of 100 and 200 ppm reduced food consumption and weight gain, particularly during the first week. By week 7, the animals had adapted to these concentrations of the chemical, and the food consumption was the same as that of the controls. The food intake or weight gain was not affected in rats fed 50 ppm of fentin hydroxide for 276 days. After 64 days of dietary exposure at 200 or 100 ppm, reduced fertility was observed in male rats, but fertility improved later, and was comparable to that of the control rats by day 113. The difference was explained by the partial stavation which the animals suffered, particularly during the first week of the experiment. Gross and microscopic examination of rats fed fentin hydroxide at the rate of 200, 100, or 50 ppm for 276 days did not reveal changes in any organ that could be related to the compound. |
| Supplementary Notes |
Pub. in Toxicology and Applied Pharmacology 12, p397-403 1968. |
| Availability Notes |
Included in the report, Journal Articles on Toxicology. Group 16, PB-280 830. |
| Title Annotations |
Reprint: Toxicity of Fentin Hydroxide to Rats, |
| PUB Date Free Form |
30 Nov 67 |
| Category Codes |
6T; 57Y |
| NTIS Prices |
(Order as PB-280 830, MF A01) |
| Primary Description |
500/01 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
323740957 |
| Origin |
NTIS |
| Type |
CAT |
