| Main Title |
Reproductive and Thyroid Effects of Low-Level Polychlorinated Biphenyl (Aroclor 1254) Exposure. |
| Author |
Gray, L. E. ;
Ostby, J. ;
Marshall, R. ;
Andrews, J. ;
|
| CORP Author |
ManTech Environmental Technology, Inc., Research Triangle Park, NC.;Health Effects Research Lab., Research Triangle Park, NC. Developmental Toxicology Div. |
| Publisher |
1993 |
| Year Published |
1993 |
| Report Number |
EPA/600/J-93/397; |
| Stock Number |
PB93-236347 |
| Additional Subjects |
Reproduction(Biology) ;
Aroclors ;
Thyroid gland ;
Thyroid hormones ;
Rats ;
Testis ;
Sperm motility ;
Organ weight ;
Testosterone ;
Body weight ;
Reprints ;
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB93-236347 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
6p |
| Abstract |
The current study was conducted to evaluate the effects of subchronic administration of Aroclor 1254 on testicular gamete production and endocrine function. The thyroid hormone thyroxine (T4), which is critical for reproduction and development, was also measured because of the well-documented effects of PCBs on this hormone. Weanling (31-day-old) male Fischer rats were administered 0, 0.1, 1, 10, or 25 mg/kg/day Aroclor 1254 by gavage for 5, 10, or 15 weeks and necropsied. In the high-dose group, body, seminal vesicle, cauda epididymal, and pituitary weights were depressed at 10 and 15 weeks and cauda epididymal sperm numbers were reduced after 15 weeks of dosing. In contrast, testes weights, testicular sperm numbers, sperm motility, and serum and testicular testosterone levels were unaffected, even in the highest dose group (25 mg/kg/day). Aroclor 1254 administration produced histological alterations in the liver and kidney at doses of 1.0 mg/kg/day and above. These results indicate that the testis of the rat is not a specific target organ for Aroclor 1254. |
| Supplementary Notes |
Pub. in Fundamental and Applied Toxicology, v20 n3 p288-294 Apr 93. See also PB90-146085. Sponsored by Health Effects Research Lab., Research Triangle Park, NC. Developmental Toxicology Div. |
| NTIS Title Notes |
Journal article. |
| Title Annotations |
Reprint: Reproductive and Thyroid Effects of Low-Level Polychlorinated Biphenyl (Aroclor 1254) Exposure. |
| Category Codes |
57Y; 57S; 68G |
| NTIS Prices |
PC A02/MF A01 |
| Primary Description |
600/10 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
330925735 |
| Origin |
NTIS |
| Type |
CAT |
