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Main Title High Concentrations of Sodium Chloride Induce a 'Positive' Response at the TK Locus of L5178Y/TK(+)/(-)Mouse Lymphoma Cells (Journal Version).
Author Moore, M. M. ; Brock, K. H. ;
CORP Author Environmental Health Research and Testing, Inc., Research Triangle Park, NC.;Health Effects Research Lab., Research Triangle Park, NC. Genetic Toxicology Div.
Publisher c1988
Year Published 1988
Report Number EPA-68-02-4456; EPA/600/J-88/239;
Stock Number PB89-145072
Additional Subjects Sodium chloride ; Bioassay ; Cytology ; Mice ; Toxicity ; Thymidines ; Reprints ; Mutagenicity tests ; Stem cells
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NTIS  PB89-145072 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 6p
Abstract The experiment with sodium chloride demonstrates the importance of carefully evaluating weak mutagenic responses observed with high concentrations of test compounds. The positive mutagenicity is likely not due to a direct interaction with DNA but from some indirect mechanism resulting from the extremely nonphysiological condition of the test. A 'blind testing scheme' might conclude that sodium chloride should be tested in the rodent bioassay. For short-term tests to be useful, all results must be carefully analyzed and evaluated using all available information including the likelihood that the test conditions may impact the outcome. To do otherwise compromises the utility of the particular test systems.
Supplementary Notes Pub. in Environmental and Molecular Mutagenesis, v12 p265-268 1988. Sponsored by Health Effects Research Lab., Research Triangle Park, NC. Genetic Toxicology Div.
NTIS Title Notes Journal article.
Title Annotations Reprint: High Concentrations of Sodium Chloride Induce a 'Positive' Response at the TK Locus of L5178Y/TK(+)/(-)Mouse Lymphoma Cells (Journal Version).
Category Codes 57F; 57Y
NTIS Prices PC A02/MF A01
Primary Description 600/11
Document Type NT
Cataloging Source NTIS/MT
Control Number 908928049
Origin NTIS
Type CAT