| Main Title |
Risk assessment on (2,4,5-trichlorophenoxy) acetic acid (2,4,5-T), (2,4,5-trichlorophenoxy) propionic acid, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) / |
| CORP Author |
United States. Carcinogen Assessment Group. |
| Publisher |
U.S. Environmental Protection Agency, Carcinogen Assessment Group ; Available from the National Technical Information Service, |
| Year Published |
1981 |
| Report Number |
EPA 600-6-81-003 |
| Stock Number |
PB 81-234825 |
| OCLC Number |
09337201 |
| Subjects |
Tetrachlorodibenzodioxin--Toxicology
|
| Additional Subjects |
Toxicology ;
Pesticides ;
Carcinogens ;
Dosage ;
Chlorine organic compounds ;
Laboratory animals ;
Mice ;
Rats ;
Malignant neoplasms ;
Epidemiology ;
Dioxin/tetrachloro-dibenzo ;
Carcinogenesis ;
Toxic substances ;
Silvex ;
T 2-4-5 herbicide ;
Cancer
|
| Internet Access |
|
| Local Library Info |
| Library |
Local Subject |
Local Note |
| EJB |
CAS no. 1746-01-6 |
|
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| EJBD |
EPA 600-6-81-003 |
c.1-2 |
Headquarters Library/Washington,DC |
08/29/2011 |
| ELBD ARCHIVE |
EPA 600-6-81-003 |
Received from HQ |
AWBERC Library/Cincinnati,OH |
10/04/2023 |
| ESAD |
EPA 600-6-81-003 |
|
Region 10 Library/Seattle,WA |
03/23/2010 |
| NTIS |
PB81-234825 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
1 volume (various pagings) : illustrations ; 28 cm |
| Abstract |
Carcinogenic responses have been induced in mice and rats at low doses of TCDD. TCDD has been shown to be a cancer promoter. These results, together with the strongly suggestive evidence in epidemiology studies, constitute substantial evidence that TCDD is likely to be a human carcinogen. It appears that TCDD is a more potent carcinogen than aflatoxin B1 which is one of the most potent carcinogens known. The levels of TCDD (contained as an unavoidable contaminant of the 2,4,5-T) used in the 2,4,5-T studies apparently were too small to produce an observable response in those experiments. The lack of a statistically significant tumor incidence in most of the studies on the 2,4,5-T product may be attributed to the very low levels of TCDD in the product relative to the levels at which it produced carcinogenic effects in rats and mice, as well as to deficiencies of those studies. However, since TCDD is a carcinogen, any product containing TCDD, including 2,4,5-T and silvix, can be considered to pose a human carcinogenic hazard. Furthermore, a rat study on specially purified 2,4,5-T provides highly suggestive evidence that essentially pure 2,4,5-T may be a human carcinogen. Quantitative assessments have been calculated for the carcinogenic risk posed to humans. |
| Notes |
Prepared for [the] Office of the General Counsel, U.S. Environmental Protection Agency. Prepared by [the] Office of Health and Environmental Assessment, Washington, D.C., Carcinogen Assessment Group. "PB 81-234825." Includes bibliographical references. |
| Place Published |
Washington, D.C. Springfield, Va. |
| Access Notes |
Also available on the Internet. |
| Corporate Au Added Ent |
United States. Environmental Protection Agency. Office of Health and Environmental Assessment. |
| PUB Date Free Form |
1981 |
| NTIS Prices |
PC A12/MF A01 |
| BIB Level |
m |
| Cataloging Source |
OCLC/T |
| OCLC Time Stamp |
20090309140312 |
| Language |
eng |
| Origin |
OCLC |
| Type |
CAT |
| OCLC Rec Leader |
01667cam 2200325Ii 45020 |
