Main Title |
Neurotoxicant 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) Alters Immune Function When Given in Combination with Diethyldithiocarbamate (DDC). |
Author |
Miller, D. B. ;
Luebke, R. W. ;
Reinhard, J. ;
O'Callaghan., J. P. ;
|
CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. ;Wellcome Research Labs., Research Triangle Park, NC. |
Publisher |
1991 |
Year Published |
1991 |
Report Number |
EPA/600/D-91/191; |
Stock Number |
PB91-231092 |
Additional Subjects |
Toxicity ;
Nervous system ;
Diethyldithiocarbamate ;
Immune system ;
Dose-response relationships ;
Drug synergism ;
Spleen ;
Thymus gland ;
Tyrosine hydroxylase ;
Organ weight ;
Concanavalin A ;
Phytohemagglutinins ;
Methylphenyltetrahydropyridine
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB91-231092 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
7p |
Abstract |
The T-cell suppression induced by the dopaminergic neurotoxicant, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) can be reversed if treatment is preceeded by low dosages of diethyldithocarbamate (DDC). However, if the dosage of DDC is high enough to potentiate the neurotoxicity associated with MPTP, thymic and spleen involution occur suggesting this dosing regimen may impair immune function. Thus, the immunotoxic and neurotoxic effects of the high dose regimen were studied. |
Supplementary Notes |
Prepared in cooperation with Wellcome Research Labs., Research Triangle Park, NC. |
Category Codes |
57Y; 57J |
NTIS Prices |
PC A02/MF A01 |
Primary Description |
600/10 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
128229344 |
Origin |
NTIS |
Type |
CAT |