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OLS Field Name OLS Field Data
Main Title Behavioral Toxicity of Acute and Subacute Exposure to Triethyltin in the Rat.
Author Reiter, Lawrence ; Kidd, Karen ; Heavner, Glendora ; Ruppert, Patricia ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1981
Report Number EPA-600/J-80-330;
Stock Number PB82-118233
Additional Subjects Toxicology ; Signs and symptoms ; Exposure ; Rats ; Laboratory animals ; Bioassay ; Pathology ; Reprints ; Triethyltin ; Toxic substances
Holdings
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Modified
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Status
NTIS  PB82-118233 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 06/23/1988
Collation 16p
Abstract Triethyltin (TET), the most toxic of the alkyltin compounds is used industrially as both a catalyst and a biocide (NIOSH, 1976). Stoner et al. (1955) determined the acute toxicity of a series of alkyltins and reported that in the rat, the LD50 for TET was 5.7 mg/kg. Barnes and Stoner (1958) reported that this toxicity was independent of the route of administration. Within 30 min. of exposure to 10 mg/kg, animals exhibited generalized weakness, especially in the hindlimbs. In more severe cases, this condition progressed to both hindlimb and forelimb paralysis. Magee et al. (1957) reported that TET produced a striking interstital edema in the white matter of both the brain and spinal cord characterized by split myelin sheaths which were dilated and filled with fluid (spongy degeneration). The spongy degeneration produced by TET is similar to that observed in rats with hexachlorophene intoxication (Cammer et al., 1975) and has been reported in monkeys and cats (Hedges and Zaren, 1969). This effect is reversible after termination of exposure (Magee et al., 1957) and also occurs in peripheral nerves (Graham and Gonatas, 1973). TET-induced brain edema is associated with a reduction in total myelin content of the brain although the chemical composition of the myelin is normal (Eto et al., 1971). No change in the blood-brain barrier to trypan blue has been found (Aleu et al., 1963).
Supplementary Notes Pub. in Neurotoxicology 2, p97-112 1980.
NTIS Title Notes Journal article.
Title Annotations Reprint: Behavioral Toxicity of Acute and Subacute Exposure to Triethyltin in the Rat.
PUB Date Free Form Sep 81
Category Codes 6T; 6E; 57Y; 57O
NTIS Prices PC A02/MF A01
Primary Description 600/11
Document Type NT
Cataloging Source NTIS/MT
Control Number 323806770
Origin NTIS
Type CAT