| Main Title |
Individual and Combined Cytotoxic Effects of Cadmium, Copper, and Nickel on Brown Cells of 'Mercenaria mercenaria'. |
| Author |
Zaroogian, G. ;
Anderson, S. ;
Voyer, R. A. ;
|
| CORP Author |
Environmental Research Lab., Narragansett, RI. |
| Publisher |
c1991 |
| Year Published |
1991 |
| Report Number |
EPA/600/J-93/308 ;ERLN-1340; |
| Stock Number |
PB93-229300 |
| Additional Subjects |
Water pollution effects(Animals) ;
Toxicity ;
Cadmium ;
Copper ;
Nickel ;
Cells(Biology) ;
Cell survival ;
Divalent cations ;
In vitro analysis ;
Lysosomes ;
Reprints ;
Mercenaria mercenaria ;
Brown cells
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB93-229300 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
13p |
| Abstract |
An assay based on the lysosomal incorporation of neutral red dye by brown cells of Mercenaria mercenaria (Bivalvia) was used to measure the cytotoxicity of Cd(sup 2+), Cu(sup 2+), and Ni(sup 2+) singly and in combination. Cytotoxicity was a linear function of Cd(sup 2+) concentration 0.1-1.5 mM and Cu(sup 2+) concentration between 10 and 100 microM. Nickel was not cytotoxic at concentrations as high as 10 mM. The presence of Cu(sup 2+) lessened the cytotoxic effect of Cd(sup 2+). Ni(sup 2+) did not affect cytotoxicity in combination with either Cu(sup 2+) or Cd(sup 2+). Ni(sup 2+) inflated estimates of cell survival by the neutral red assay in this study. Cells exposed to Ni(sup 2+) yielded measured quantities of neutral red dye in excess of those measured in cells from control treatments. (Copyright (c) 1992 Academic Press, Inc.) |
| Supplementary Notes |
Pub. in Ecotoxicology and Environmental Safety 24, p328-337, 1992. See also PB91-117515 and PB93-204949. |
| NTIS Title Notes |
Journal article. |
| Title Annotations |
Reprint: Individual and Combined Cytotoxic Effects of Cadmium, Copper, and Nickel on Brown Cells of 'Mercenaria mercenaria'. |
| Category Codes |
68D; 57Y |
| NTIS Prices |
PC A03/MF A01 |
| Primary Description |
600/05 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
328023384 |
| Origin |
NTIS |
| Type |
CAT |
