| Main Title |
Fimbria-Fornix Transections Disrupt the Ontogeny of Delayed Alternation but Not Position Discrimination in the Rat. |
| Author |
Freeman, J. H. ;
Stanton., M. E. ;
|
| CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. ;North Carolina Univ. at Chapel Hill. |
| Publisher |
c1991 |
| Year Published |
1991 |
| Report Number |
EPA/600/J-91/160; |
| Stock Number |
PB91-231282 |
| Additional Subjects |
Surgery ;
Ontogenesis ;
Discrimination learning ;
Rats ;
Histology ;
Animal behavior ;
Acetylcholinesterase ;
Hippocampus ;
Immunohistochemistry ;
Reprints ;
Fimbria-fornix transections
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB91-231282 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
12p |
| Abstract |
In Experiment 1, Long-Evans rat pups received fimbria-fornix transections or sham surgery on Postnatal Day 10 (PND10) and were then trained on PND23 to perform either a discrete-trials delayed alternation (DA) or a simple position discrimination (PD) task in a T maze. Rat pups in both surgical conditions learned the PD task within five 12-trial blocks of training. However, only sham-operated pups learned the DA task. In Experiment 2, performance of DA emerged between PND19 and PND27 in sham-operated pups but failed entirely to develop in pups with early lesions. In Experiment 3, fornix-transected pups that were given extended DA training (132 trials) on PND23-PND24 showed some improvement in performance but remained impaired in relation to sham-operated controls. These findings implicate the limbic system in the postnatal development of DA but not PD and suggest that dual-process theories of memory may be relevent to the psychobiology of cognitive development. |
| Supplementary Notes |
Pub. in Behavioral Neuroscience, v105 n3 p386-395 Jun 91. Prepared in cooperation with North Carolina Univ. at Chapel Hill. |
| NTIS Title Notes |
Journal article. |
| Title Annotations |
Reprint: Fimbria-Fornix Transections Disrupt the Ontogeny of Delayed Alternation but Not Position Discrimination in the Rat. |
| Category Codes |
57X; 57S |
| NTIS Prices |
PC A03/MF A01 |
| Primary Description |
600/10 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
128229530 |
| Origin |
NTIS |
| Type |
CAT |
