| Main Title |
Computer-Automated Structure Evaluation of Antileukemic 9-Anilinoacridines. |
| Author |
Klopman, G. ;
Macina, O. T. ;
|
| CORP Author |
Case Western Reserve Univ., Cleveland, OH. Dept. of Chemistry.;Health Effects Research Lab., Research Triangle Park, NC.;Office of Naval Research, Arlington, VA. |
| Publisher |
c1987 |
| Year Published |
1987 |
| Report Number |
EPA-R-812264; EPA/600/J-87/488; |
| Stock Number |
PB90-111600 |
| Additional Subjects |
Antineoplastic agents ;
Acridines ;
Pharmacology ;
Tables(Data) ;
Deoxyribonucleic acids ;
In vitro analysis ;
Reprints ;
Leukemia L1210 ;
9-Anilinoacridines ;
Computer automated structure evaluation(CASE) ;
Structure-activity relationship ;
Dose-reponse relationships ;
Predictive value of tests
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB90-111600 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
22p |
| Abstract |
The computer-automated structure evaluation (CASE) program has been applied to the evaluation of antileukemic (L1210) and toxic activities of an extensive series of 9-anilinoacridines. Major molecular fragments relevant to the respective biological end-points were automatically generated and incorporated within equations used to estimate the degree of activity. Correlations of these activating/inactivating fragments with the biological activities are discussed. (Copyright (c) The American Society for Pharmacology and Experimental Therapeutics.) |
| Supplementary Notes |
Pub. in Molecular Pharmacology, v31 p457-476 1987. Sponsored by Health Effects Research Lab., Research Triangle Park, NC., and Office of Naval Research, Arlington, VA. |
| NTIS Title Notes |
Journal article. |
| Title Annotations |
Reprint: Computer-Automated Structure Evaluation of Antileukemic 9-Anilinoacridines. |
| Category Codes |
57Q |
| NTIS Prices |
PC A03/MF A01 |
| Primary Description |
600/10 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
935218835 |
| Origin |
NTIS |
| Type |
CAT |
