| Main Title |
Teratogenicity of 5-Azacytidine in the Sprague-Dawley Rat. |
| Author |
Rosen, M. B. ;
House, H. S. ;
Francis, B. M. ;
Chernoff., N. ;
|
| CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. ;NSI Technology Services Corp., Research Triangle Park, NC. |
| Publisher |
cFeb 90 |
| Year Published |
1990 |
| Report Number |
EPA/600/J-90/233; |
| Stock Number |
PB91-117051 |
| Additional Subjects |
Genes ;
Deoxyribonucleic acids ;
Ribonucleic acids ;
Fetus ;
Body weight ;
Congenital abnormalities ;
Reprints ;
Teratogens ;
Azacytidine ;
Gestation ;
Inbred strains rats ;
Ontogeny ;
Dose-response relationships
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB91-117051 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
12p |
| Abstract |
5-azacytidine (5-aza), a chemical which is incorporated into DNA and RNA with consequent alterations in the expression of mammalian genes, was administered to pregnant Sprague-Dawley rats on single days during gestation. Doses of 0.5, 1, and 2 mg/kg were given by intraperitoneal injection on days 9, 10, 11, or 12. Dams were killed on day 20 of gestation and fetuses were examined for both external and skeletal defects. 5-aza affected development on all days tested. The compound was embryolethal, caused reductions in fetal weight, and had profound effects on morphological development. Digit and limb anomalies, exencephaly, micrognathia, gastroschisis, and various rib defects were observed and related to the day of exposure. (Copyright (c) 1990 by Hemisphere Publishing Corporation.) |
| Supplementary Notes |
Pub. in Jnl. of Toxicology and Environmental Health, v29 n2 p201-210 Feb 90. Prepared in cooperation with NSI Technology Services Corp., Research Triangle Park, NC. |
| NTIS Title Notes |
Journal article. |
| Title Annotations |
Reprint: Teratogenicity of 5-Azacytidine in the Sprague-Dawley Rat. |
| Category Codes |
57Y; 57S; 57F |
| NTIS Prices |
PC A03/MF A01 |
| Primary Description |
600/10 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
101123865 |
| Origin |
NTIS |
| Type |
CAT |
