Main Title |
Endogenously-Mediated, Pretranslational Suppression of Cytochrome P4501A in PCB-Contaminated Flounder. |
Author |
Elskus, A. A. ;
Pruell, R. ;
Stegeman, J. J. ;
|
CORP Author |
Woods Hole Oceanographic Institution, MA. ;Marine Biological Lab., Woods Hole, MA.;Environmental Research Lab., Narragansett, RI. |
Publisher |
c1992 |
Year Published |
1992 |
Report Number |
EPA-R813155 ;PHS-ES04220; EPA/600/J-94/002 ; ERLN-1322 |
Stock Number |
PB94-140787 |
Additional Subjects |
Flat fishes ;
Chlorinated organic compounds ;
Pollution ;
Sex ;
Maturation ;
Biphenyl ;
Chlorine organic compounds ;
Females ;
Males ;
Hormones ;
Concentration(Composition) ;
Steroids ;
Reprints ;
Cytochrome P4501A ;
Flounder ;
Polychlorinated biphenyl ;
Pseudopleuronectes americanus ;
Inducers
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB94-140787 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
7p |
Abstract |
Gonadally mature fish display strong sex-related differences in the content and activity of P4501A, the major polynuclear aromatic hydrocarbon-inducible P450 form in teleosts. Such differences appear related to plasma levels of the female sex steroid, estradiol (E2); however, neither the mechanism of estradiol suppression of P4501A nor the capacity for hormonal regulation to overcome P4501A induction by high concentrations of potent inducers are known. Gonadally mature flounder (Pseudopleuronectes americanus) were collected from Fox Island (FI), Rhode Island, a reference site, and New Bedford Harbor (NB), Massachusetts, a site highly contaminated with polychlorinated biphenyls. Differences in flounder P4501A expression were determined at the level of P4501A catalytic activity (measured as ethoxyresorufin-O-deethylase, EROD), P4501A protein content (immunoquantitated), and P4501A mRNA content (by Northern blot) as they relate to sex, reproductive status and hepatic PCB content. (Copyright (c) 1992 Elsevier Science Publishers Ltd, England.) |
Supplementary Notes |
Pub. in Marine Environmental Research, v34 p97-101 1992. Prepared in cooperation with Marine Biological Lab., Woods Hole, MA. Sponsored by Environmental Research Lab., Narragansett, RI. |
NTIS Title Notes |
Journal article. |
Title Annotations |
Reprint: Endogenously-Mediated, Pretranslational Suppression of Cytochrome P4501A in PCB-Contaminated Flounder. |
Category Codes |
47D; 68D |
NTIS Prices |
PC A02/MF A01 |
Primary Description |
600/05 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
409119449 |
Origin |
NTIS |
Type |
CAT |