||Letter from Synthetic Organic Chemical Manufactures Assoc. to the USEPA Submitting Information on the Results of a 14 Week Inhalation Study in Rats Exposed to Diethylethanolamine.
||Synthetic Organic Chemical Manufacturers Association, Inc., Washington, DC.;Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
||29 Jun 1989
Nasal mucosa ;
Fischer F-344 rats ;
Multifocal mixed inflammatory cell infiltration ;
Dose-related histologic changes ;
Nasal turbinates ;
Nasal cavities ;
Focal hyperplasia ;
Squamous metaplasia ;
||Some EPA libraries have a fiche copy filed under the call number shown.
||Fischer F-344 adult rats were exposed to airborne vapor concentrations of 0, 10, 25 or 75 ppm of DEEA for 14 weeks (6 hrs/day x 5 day's wk). Groups of animals were sacrificed immediately following the 14 week exposure as well as after a 4 week post-exposure or recovery period. No exposure-related microscopic changes were observed in any of the rats exposed to 10 ppm whether sacrificed immediately after the 14 week exposure or after a 4 week recovery period. Dose-related histological changes were observed in nasal turbinates and nasal cavities in rats exposed 14 weeks to 25 ppm or to 75 ppm. Such findings consisted of an increased incidence and severity, viz., minimal to slight to moderate, of focal hyperplasia alone and focal hyperplasia with squamous metaplasia of respiratory epithelium and multifocal mixed inflammatory cell infiltration of nasal mucosa. In the 75 ppm group, some rats experienced hypertrophy of goblet cells on the nasal septum and a low incidence of focal necrosis and exudate in the lumen of the nasal cavity.
||The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Prepared in cooperation with American Petroleum Inst., Washington, DC.
||Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at firstname.lastname@example.org. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA.
||PC A03/MF A01