| Main Title |
Effects of 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) on Humoral Immunity and Lymphocyte Subpopulations: Differences between Mice and Rats. |
| Author |
Smialowicz, R. J. ;
Riddle, M. M. ;
Williams, W. C. ;
Diliberto, J. J. ;
|
| CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. Environmental Toxicology Div. |
| Publisher |
c1994 |
| Year Published |
1994 |
| Report Number |
EPA/600/J-94/320; |
| Stock Number |
PB94-197167 |
| Additional Subjects |
Tetrachlorodibenzodioxin ;
Toxicology ;
Immunity ;
Lymphocyte subsets ;
Mice ;
Rats ;
Species diversity ;
Antibody formation ;
Cytochrome P-450 ;
Reprints ;
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB94-197167 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
5p |
| Abstract |
In the study, the effect that 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) has on the antibody plaque-forming cell (PFC) response to sheep red blood cells (SRBC) in adult female B6C3F1 mice and F344 rats was compared. The effect that TCDD has on the PFC response of male F344 and female Long-Evans rats was also determined. Mice or rats were given a single intraperitoneal injection of TCDD at doses ranging from 0.1 to 30 micrograms/kg, 7 days prior to intravenous immunization with SRBC. Four days later the PFC response to SRBC was determined. Results demonstrate species differences in the effect of TCDD on the PFC response to SRBC which were unrelated to hepatic CYP1A1 or CYP1A2 induction, time to peak response, gender, and strain. The failure of TCDD to suppress and in fact to enhance the PFC response to SRBC in rats appears to be related to alterations in splenic CD4(-)CD8(+) lymphocytes. |
| Supplementary Notes |
Pub. in Toxicology and Applied Pharmacology, v124 n2 p248-256 Feb 94. Presented at the Annual Meeting of the Society of Toxicology, New Orleans, LA., 1993. |
| NTIS Title Notes |
Journal article. |
| Title Annotations |
Reprint: Effects of 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) on Humoral Immunity and Lymphocyte Subpopulations: Differences between Mice and Rats. |
| Category Codes |
57Y; 57J |
| NTIS Prices |
PC A01/MF A01 |
| Primary Description |
600/10 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
425927250 |
| Origin |
NTIS |
| Type |
CAT |
