| Main Title |
Analysis of Alkyl Phosphates by Extractive Alkylation. |
| Author |
Bradway, Diane E. ;
Moseman, Robert ;
May, Randy ;
|
| CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. Analytical Chemistry Branch. |
| Year Published |
1981 |
| Report Number |
EPA-600/J-81-033; |
| Stock Number |
PB82-124231 |
| Additional Subjects |
Pesticides ;
Chemical analysis ;
Urine ;
Organic phosphates ;
Solvent extraction ;
Isomers ;
Concentration(Composition) ;
Reprints ;
Phosphorothioic acid/(dimethyl-ester) ;
Phosphorothioic acid/(diethyl-ester)
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB82-124231 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
6p |
| Abstract |
The development of suitable methods for analysis of the alkyl phosphate metabolites of organophosphorus pesticides in urine has been a rather difficult and persistent problem. Currently available methodology suffers from several shortcomings. The extraction of the compounds from urine is often incomplete and inconsistent. The reagent used in derivatization, diazopentane, and its precursor, a substituted nitrosoguanidine, present unacceptable hazards to the analyst, principally because of the demonstrated mutagenicity and/or carcinogenicity of the reagents. In addition, when dimethylphosphorothioate and diethylphosphorothioate are derivatized with diazoalkanes, they to give two isomeric products: a phosphorothionate and a phosphorothiolate. It is therefore, uncertain that the ratio of the isomers is constant. The limit of detection is higher than would be the case if only one product were formed. |
| Supplementary Notes |
Pub. in Bulletin of Environmental Contamination Toxicology 26, p520-523 1981. |
| NTIS Title Notes |
Journal article. |
| Title Annotations |
Reprint: Analysis of Alkyl Phosphates by Extractive Alkylation. |
| PUB Date Free Form |
Sep 81 |
| Category Codes |
7D; 6E; 68E; 99A; 57D |
| NTIS Prices |
PC A02/MF A01 |
| Primary Description |
600/11 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
323807252 |
| Origin |
NTIS |
| Type |
CAT |
