| Main Title |
Thirteen Week Inhalation Toxicity Study of Commercial Hexane in the Rat and Mouse Pathology Report. |
| CORP Author |
Experimental Pathology Labs., Inc., Research Triangle Park, NC. ;American Petroleum Inst., Washington, DC.;Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Publisher |
7 Nov 1989 |
| Year Published |
1989 |
| Report Number |
FYI-OTS-1189-0714; |
| Stock Number |
OTS-0000714-1 |
| Additional Subjects |
Inhalation ;
Toxicity ;
Hexane ;
Rats ;
Mice ;
Kidney ;
Exposure ;
Eosin ;
Pathology ;
Lesions ;
Tubular dilation ;
Fischer 334 rats ;
B(sub 6)C(sub 3)F(sub 1) mice ;
Hematoxylin ;
Kidney slides ;
Mallory Heidenhain ;
Hydrocarbon induced kidney changes ;
Hyaline droplet change ;
Regenerative epithelium
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS-0000714-1 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
32p |
| Abstract |
Fischer 344 rats and B(sub 6)C(sub 3)F(sub 1) mice were divided into groups and treated. The 'in-life' part of this study was conducted at Bio/dynamics (Project Number 89-819-1: A=Rats, B=Mice). Duplicate sections from each kidney specimen (high and control animals) were prepared and mounted at Bio/dynamics. The first series was processed to hematoxylin and eosin stained slides at Bio/dynamics. All hemotoxylin and eosin and unstained kidney slides were sent to Experimental Pathology Laboratories (EPL) where a second series was stained with Mallory Heidenhain stain according to the attached procedure. The purpose of this study was to evaluate hydrocarbon induced kidney changes by grading hyaline droplet change, regenerative epithelium and by estimating tubular dilatation with granular material as per the attached criteria. All slides were evaluated coded or in a 'blind' manner, the computer assigning random numbers to the slides for each animal regardless of treatment group. The slides were then examined 'blind' and the renal lesions dictated. The Pathology Support Groups at EPL entered the diagnoses into the computer which then decoded the results, issuing Histopathology Incidence and Summary Tables. |
| Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Prepared in cooperation with American Petroleum Inst., Washington, DC. |
| Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. |
| Category Codes |
57O |
| NTIS Prices |
PC A04/MF A01 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
019103480 |
| Origin |
NTIS |
| Type |
CAT |
